Fine grain carriers and medicinal composition prepared with the

Details Fine grain carriers and medicinal composition prepared with the Fine grain carriers and medicinal composition prepared with the

1998-08-21

2000-08-08

Kulkosky, Peter F.

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

Mixing of two or more solid polymers; mixing of solid...

525217, 525227, 525230, 526286, 526304, 5263076, 5263077, 42721334, A61K 914, A61K 4730

Patent

active

061003387

DESCRIPTION:

BRIEF SUMMARY
TECHNICAL FIELD

The present invention relates to particulate carriers which are useful as drug carriers in a drug delivery system (DDS) and to pharmaceutical compositions containing the carriers.


BACKGROUND ART

In the field of DDS, the term "drug carriers" is used to refer to carriers that deliver drugs to target organs or cells. When drug carriers are in the form of particles, they are called particulate carriers. Particulate carriers are classified into microcapsules, microspheres, nanoparticles, etc. according to their sizes, shapes, and functions. Materials for preparing particulate carriers include lipids, polymers, etc.
The terms "microcapsules" and "microspheres" are usually used to refer to particles whose diameter is several micrometers. Microcapsules are generally considered to embrace a broader category than microspheres. Particles formed of a polymer from the surface to the core are often distinguished from microcapsules and are referred to as microspheres these days.
The term "nanoparticles" has conventionally been used to refer to polymeric colloids prepared through emulsion polymerization, as the particles size is on the order of several nanometers. However, it has recently become common practice to collectively refer to particles composed of natural or synthetic polymers, even though prepared through methods other than emulsion polymerization, as nanoparticles so long as the particle diameter is on the order of several nanometers.
Nanoparticles as particulate carriers were first studied for use as carriers for targeting, for example, anti-cancer agents. In the early studies, the primary object of application was injection (L. Grislain et al., International Journal of Pharmaceutics, 15, 335 (1984)). Since the mid 1980's, studies of nanoparticles as oral dosage forms have come to be reported .
When drugs are prepared as the form of nanoparticles and used as oral dosage forms, the following are considered goals to attain: improvement of drugs with poor absorptive characteristic (P. Maincent et al., Journal of Pharmaceutical Sciences, 75, 955 (1986); C. Damge et al., International Journal of Pharmaceutics, 36, 121 (1987)), oral dosage forms of peptide drugs such as insulin (C. Damge et al., Diabetes, 37, 246 (1988); P. Couvreur and F. Puisieux, Advanced Drug Delivery Reviews, 10, 141 (1993)), oral delivery of vaccines antigen (J. H. Eldrige, Journal of Controlled Release, 11, 205 (1990)t; P. U. Jani et al., International Journal of Pharmaceutics, 86, 239 (1992)), and controlled release of drugs (B. Hubert et al., Pharmaceutical Research, 8, 734 (1991)).
Moreover, like the case of microcapsules, nanoparticles are sometimes used in an attempt to ensure stability of drugs in gastrointestinal tract (M. Rogues et al., Diabetes, 41, 451 (1992)) or to reduce irritation caused by strongly stimulative drugs on gastrointestinal mucosa (N. Ammoury et al., Pharmaceutical Research, 8, 101 (1991)).
Nanoparticles for pharmaceutical use are principally prepared by one of the two methods. The first method is a typical microcapsulation method, which is practiced through phase separation or solvent evaporation.
When this method is practiced, there are usually used hydrophobic polymers that have customarily been used as additives for pharmaceuticals, such as polylactic acid (A. M. Ray et al., Journal of Pharmaceutical Sciences, 83, 845 (1994)), cellulose derivatives (H. Ibrahim et al., International Journal of Pharmaceutics, 87, 239 (1992), or polyacrylate derivatives (E. Allemann et al., International Journal of Pharmaceutics, 87, 247 (1992)).
The other method for the preparation of nanoparticles makes use of emulsion polymerization (L. Vansnick et al., Pharmaceutical Research, 1, 36 (1985); N. Al Khouri Fallouh et al., International Journal of Pharmaceutics, 28, 125 (1986)). In this case, hydrophobic polyvinyl compounds such as polystyrene, polyacrylate, and polymethacrylate are considered to serve as the material of the nanoparticles. Polycyanoacrylates are used quite often, especially polyisobutyl cyanoacr

REFERENCES:
patent: 2811507 (1957-10-01), D'Alelio
patent: 4008202 (1977-02-01), Evani et al.
patent: 4011201 (1977-03-01), Ponticello
patent: 5061761 (1991-10-01), Sato et al.
patent: 5250629 (1993-10-01), Tani et al.
Chem. Ab. vol. 123:286978 H.-O. Kim et al, Apr. 1993.
C.Ab. 125:143400, Feb. 1996.
C.Ab. 125:59765, Jan. 1995.

Affiliated with

Also associated with

Rating

Fine grain carriers and medicinal composition prepared with the does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Fine grain carriers and medicinal composition prepared with the , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Fine grain carriers and medicinal composition prepared with the will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1150891