Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Particulate form
Patent
1994-08-11
1998-09-15
Bawa, Raj
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Particulate form
424 781, 424 7808, 424451, 424464, 424501, 523400, 514951, A61K 914, A61K 920
Patent
active
058075828
ABSTRACT:
The present invention provides for an improvement in the emulsion copolymerization process for the preparation of fine-beaded colestipol hydrochloride (FBCH) wherein the improvement comprises: 1) utilizing a weight ratio of water to polyethylenepolyamine in the process of 1.8 to 3.6 grams per gram, and 2) utilizing a weight ratio of surface active agent or surfactant to polyethylenepolyamine in the process of 1.0 to 3.0 grams per kilogram. The colestipol hydrochloride product thus produced is a novel fine-beaded form of a known pharmaceutical composition, yielding pharmaceutically elegant dosage forms exhibiting increased potency, including non-gritty oral powders and oral tablets. Conventional colestipol hydrochloride was heretofore available in large spherical granules which produced less elegant (gritty) oral suspensions.
REFERENCES:
patent: 3692895 (1972-09-01), Nelson
patent: 3803237 (1974-04-01), Lednicer
patent: 4439419 (1984-03-01), Vecchio
patent: 4631305 (1986-12-01), Guyer
Bawa Raj
Gammill Martha A.
Pharmacia & Upjohn Company
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