Finderons and methods of their preparation and use

Details Finderons and methods of their preparation and use Finderons and methods of their preparation and use

1995-06-07

1997-07-08

Ketter, James

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing saccharide radical

435 6, 536 231, C12P 1934, C12Q 168, C07H 2102, C07H 2104

Patent

active

056460210

ABSTRACT:
Disclosed is a finderon having the ability to endonucleolytically cleave a sequence of 3' to 5' linked ribonucleotides. The finderon includes a rigid linker comprising at least one non-nucleotidic unit, flanked by first and second flanking regions of at least four contiguous, covalently-linked nucleotides. At least a portion of each flanking region is complementary to a target region on a substrate RNA molecule. Also disclosed are methods of preparing and using a finderon, and kits including a finderon.

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