Finderons and methods of their preparation and use

Details Finderons and methods of their preparation and use Finderons and methods of their preparation and use

1994-09-29

1997-12-23

Ketter, James

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 245, C07H 2100

Patent

active

057009236

ABSTRACT:
Disclosed is a finderon having the ability to endonucleolytically cleave a sequence of 3' to 5' linked ribonucleotides. The finderon includes a rigid linker comprising at least one non-nucleotidic unit, flanked by first and second flanking regions of at least four contiguous, covalently-linked nucleotides. At least a portion of each flanking region is complementary to a target region on a substrate RNA molecule. Also disclosed are methods of preparing and using a finderon, and kits including a finderon.

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