Finderons and methods of their preparation and use

Details Finderons and methods of their preparation and use Finderons and methods of their preparation and use

1995-06-07

1997-10-21

Ketter, James

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing saccharide radical

435 6, 536 231, C12P 1934, C12Q 168, C07H 2102, C07H 2104

Patent

active

056795548

ABSTRACT:
Disclosed is a finderon having the ability to endonucleolytically cleave a sequence of 3' to 5' linked ribonucleotides. The finderon includes a rigid linker comprising at least one non-nucleotidic unit, flanked by first and second flanking regions of at least four contiguous, covalently-linked nucleotides. At least a portion of each flanking region is complementary to a target region on a substrate RNA molecule. Also disclosed are methods of preparing and using a finderon, and kits including a finderon.

REFERENCES:
patent: 4987071 (1991-01-01), Cech et al.
patent: 5144019 (1992-09-01), Rossi et al.
Dong-jing Fu et al. (1994) J. Am. Chem. Soc. (1994) 116:4591-4598.
Hendry et al. (1994) Biochimica et Biophysica Acta 1219:405-412.
Nesbitt et al. (1994) Antisense Research and Development 4:243-249.
Buzayan et al. (1990) Nuc. Acids Res. 18:4447-4451.
Dahm et al. (1990) Biochimie 72:819-23.
Odai et al. (1990) FEBS Lett. 267:150-152.
Perreault et al. (1990) Nature 344:565-567.
Ruffner et al. (1990) Nucleic Acids Res. 18:6025-6029.
Goodchild et al. (1991) Arch. Biochem. Biophys. 284:386-391.
Koizumi et al. (1991) Biochem. 30:5145-5150.
Olsen et al. (1991) Biochem. 30:9735-9741.
Perreault et al. (1991) Biochem. 30:4020-4025.
Pieken et al. (1991) Science 253:314-317.
McCall et al. (1992) Proc. Natl. Acad. Sci. (USA) 89:5710-5714.
Benseler et al. (1993) J. Am. Chem. Soc. 115:8483-8484.
Ma et al. (1993) Nucleic Acids Res. 21:2585-2589.
Ma (1993) Biochem. 32:1751-1758.
Thomson et al. (1993) Nucleic Acids Res. 21:5600-5603.
Tuschl et al. (1993) Proc. Natl. Acad. Sci. (USA) 90:6991-6994.
Goodchild (1992) Nucleic Acids Research 20:4607-4612.
Morrow Adv. Inorg. Biochem. 9 41-74 (1994) Artificial Ribonucleases.

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