Filtration apparatus for separating blood cell-containing liquid

Details Filtration apparatus for separating blood cell-containing liquid Filtration apparatus for separating blood cell-containing liquid

1978-05-25

1980-07-15

Spear, Jr., Frank A.

Liquid purification or separation

Filtrate splash plate and/or deflector

210321R, 210346, 210433M, 210456, B01D 3100

Patent

active

042127424

ABSTRACT:
A filtration device for effecting separation of a blood cell-free liquid filtrate from a blood cell-containing liquid suspension in continuous laminar flow therethrough, employing a microporous filtration membrane. The filtration flow channels along the surface of the upstream side of the membrane wall are provided with a width across the membrane wall surface which gradually and uniformly increases from the inlet end to the outlet end of the flow channel, whereby the membrane wall shear rate of the suspension in laminar flow through the flow channel will gradually and uniformly vary along the length of the flow channel from a maximum value at its inlet end to a minimum value at its outlet end. Such variation in shear rate corresponds with the variation in the transmembrane pressure conditions along the length of the flow channel so as to enable better control of the filtration operating conditions to insure optimal filtration rates per area of membrane without damage to the blood cells. Useful applications of the device include the separation of plasma from whole blood in a continuous flow plasmapheresis procedure, and the removal of cryoprotective agents from previously frozen, thawed preparations of blood cells.

REFERENCES:
patent: 3362540 (1968-01-01), Bluemle, Jr.
patent: 3483867 (1969-12-01), Markovitz
patent: 3567031 (1971-03-01), Loeffler
patent: 3705100 (1972-12-01), Blatt et al.
patent: 4105547 (1978-08-01), Sahdblom
Bixler et al., "The Development of a Diatitration System for Blood Purification", from vol. XIV, Trans. Amer. Sucartle Int. Organs, 1968, pp. 99-108.
Lysaght, et al., "Development of a Microporous Membrane System for Continuous Flow Plasmapheresis", The American Society for Artificial Internal Organs, 23rd Annual Meeting, Abstract published Mar. 17, 1977, one page.

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