Filteration method for cell produced antiviral substances

Details Filteration method for cell produced antiviral substances Filteration method for cell produced antiviral substances

1981-08-13

1983-12-13

Sadowski, David R.

Liquid purification or separation

Processes

Liquid/liquid solvent or colloidal extraction or diffusing...

210645, 210648, 210651, 210181, 210182, 2101952, 2102572, 210259, 210295, 2103211, 210335, 435 68, 435240, 435241, 435803, 435811, 424 85, B01D 1300, B01D 3100

Patent

active

044203985

ABSTRACT:
This invention affords a filtration method and apparatus for extracting cell produced antiviral substances (CPAS) from a production broth using cross-flow membrane filtration. The broth is perfused into a first filtration cell and caused to cross-flow across an ultrafiltration membrane in the cell, permitting a first filtrate to pass through the membrane consisting essentially of CPAS and some molecular species and retaining in a first ex-filtrate all remaining portions of the broth.

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Kauppinen, H. L. et al. "Large Scale Production and Properties of Human Leukocyte Interferon . . . ", In, Human Interferon Production and Clinical Use, W. R. Stinebrins, Ed., Plenum Press, N.Y. 1977 pp. 1-13.
Porter, M. C. et al., "Membrane Ultrafiltration", in Chemical Tech. Jan. 1971 pp. 56-63.
Yabrov, A. A., Interferon and Nonspecific Resistance, Human Science Press, N. Y., 1980 pp. 28-31, 135, 136, 175-184.
Michaels, A. S. "New Separation Technique For The CPI", Chem. Eng. Progress, vol. 64, No. 12, 1968 pp. 31-43.

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