Filter device

Details Filter device Filter device

1995-03-31

1997-01-21

Beisner, William

Chemistry: molecular biology and microbiology

Apparatus

Bioreactor

435182, 43524022, 435240242, 4352991, 604 4, C12M 306

Patent

active

055959091

ABSTRACT:
A filter device containing cell masses and single cells is described. The device contains porous hollow fibers and hepatocytes entrapped within a contracted gel matrix.

REFERENCES:
Scholz et al. "A two-compartment cell entrapment bioreactor with three different holding times for cells, high and low molecular weight compounds." Cytotechnology, vol. 4 (1990), pp. 127-137. 1990.
Peshwa, M. V. et al., "Kinetics of hepatocyte spheroid formation", Biotechnol. Prog., 10, 460-466 (1994).
Lazar, A. et al., "Formation of porcine hepatocyte spheroids for use in a bioartificial liver", Cell Transplantation, 4, 259-268 (1995).
Lazar, A. et al., "Extended liver-specific functions of porcine hepatocyte spheroids entrapped in collagen gel", In Vitro Cell. Dev. Biol., 31, 340-346 (1995).
Wu, F. J. et al., "Entrapment of hepatocyte spheroids in a hollow fiber bioreactor as a potential bioartificial liver", Tissue Engineering, 1, 29-40 (1995).
Koide, N. et al., "Continued high albumin production by multicellular . . . ", Biochem. Biophys. Res. Comm., 161, 385-391 (1989).
Koide, N. et al., "Formation of multicellular spheroids composed of adult rat . . . ", Exp. Cell Res., 186, 227-235 (1990).
Tong, J. Z. et al., "Long-term culture of adult rat hepatocyte spheroids", Exp. Cell Res., 200, 326-332 (1992).
Li, A. P. et al., "Culturing of primary hepatocytes as entrapped aggregates . . . ", In Vitro Cell. Dev. Biol. 29A, 249-254 (1993).
Sakai, Y. et al., "A hollow fiber bioreactor immobilizing . . . ", Animal Cell Tech.: Basic & Applied Aspects, 6:417-421. Eds. T. Kobayshi et al. Kluwer Pub, Netherlands (1994).
Takabatake, H. et al., "Encapsulated multicellular spheroids of rat hepatocytes . . . ", Artif. Organs, 15 474-480 (1991).
Yagi, K. et al., "Rapid formation of multicellular spheroids of adult rat . . . ", Artif. Organs, 17, 929-934, (1993).

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