Film-forming product for coating solid forms, process for its ma

Details Film-forming product for coating solid forms, process for its ma Film-forming product for coating solid forms, process for its ma

1992-09-16

1995-02-28

Green, Anthony

Compositions: coating or plastic

Coating or plastic compositions

Proteinaceous material containing

424439, 424442, 424475, 424476, 424477, 424480, 424482, 424489, 424490, 424491, 424493, 424494, 424497, 424499, 424501, 424502, 426 96, 427212, 523100, 523105, C09D10100, C09D10500, A61K 914, A61K 930

Patent

active

053933338

DESCRIPTION:

BRIEF SUMMARY
The present invention relates in general terms to a novel film-forming product for coating solid forms, preferably of agricultural, pharmaceutical or food products, to the process for its preparation and to products coated with this film-forming product.
Numerous film-forming products are known for coating solid forms of pharmaceutical or food products. These film-forming products differ essentially in their composition and in the form which they take.
In general, these products contain cellulosic polymers, colored pigments, plasticizers and, if appropriate, various fillers.
French patent no. 2.470.598 describes a product which contains these different ingredients and which takes the form of a dry solvent-free mixture. This product can easily be dispersed in organic or aqueous solvents to give a film-forming solution capable of being sprayed on to the products to be coated, but has the disadvantage of generating soiling colored dusts when it is handled or transferred.
Moreover, this product is not free-flowing and, because of the substantial differences in the morphology and particle size of its various constituents, undesirable variations are observed in the colors of the coating.
U.S. Pat. No. 4,816,298 describes a process for the film-coating of tablets, comprising the preparation of particles consisting of hot-melt polymer, plasticizer and colored pigment.
These particles, which have a diameter of between about 1 and about 0.1 mm, do not cause dust, are stable and are easily dispersed in cold water.
However, this process requires the use of very considerable amounts (more than 30% by weight) of plasticizer in order to "solubilize" the polymer and obtain a melting/extrusion point which is not excessive. Moreover, in the Examples indicated in said document, the extrusion is carried out at a temperature of the order of 90.degree. C., which can damage the colorants or lakes required for coloring the films.
French patent 2.548.675 in the name of the Applicant describes a film-forming product which contains .alpha.-cellulose and which takes the form of nonpulverulent granules with a diameter of about 0.5 to 1 mm, in which the different constituents are homogeneously distributed.
The product thus obtained can very easily be dispersed and entails no risk of stratification.
Furthermore, for the same viscosity, the coating solutions obtained from this product are more concentrated than those obtained from the products described in French patent 2.470.598 and U.S. Pat. No. 4,816,298 and permit more rapid coating of the products to be coated.
However, the films obtained from such a product have a matt appearance and cannot easily be made shiny.
It is important to note that .alpha.-cellulose is considered and presented as an essential constituent for the production of granules because of its role as a binder and because it also ensures that the coating film adheres well to the product to be coated.
The present invention is based on the observation that the presence of .alpha.-cellulose in the granules produced according to French patent 2.548.675 results in a film with a relatively non-uniform surface which does not make it possible to give said film a shiny appearance.
The invention is based secondly on the discovery of the fact that it is possible to prepare a film-forming product, free of .alpha.-cellulose, in the form of granular particles which enable uniform non-matt films to be obtained.
The object of the present invention is therefore to solve the technical problem of providing a novel film-forming product consisting of granular particles which can easily be dispersed in an aqueous or organic solvent and which make it possible to obtain a uniform film capable of being made shiny.
The solution to this technical problem, according to the present invention, consists of a film-forming product, free of .alpha.-cellulose, for coating solid forms, said product taking the form of homogeneous granular particles which can easily be dispersed in an aqueous or organic solvent and which make it possible to obtain a unif

REFERENCES:
patent: 4543370 (1985-09-01), Porter et al.
patent: 4556552 (1985-12-01), Porter et al.
patent: 4683256 (1987-07-01), Porter et al.
patent: 4704295 (1987-11-01), Porter et al.
patent: 4816298 (1989-03-01), Alderman et al.
US Pharmacopoeia, "Powder Fineness", p. 811 & "Pharmaceutic Ingredients", pp. 1857-1859, [No date].
European Pharmacopoeia, "Granules", pp. 694-695, [No date].
Kirk-Othmer, "Encyclopedia Of Chemical Technology", Third Edition, vol. 17, pp. 871-878, [No date].
Banque de Donnees wpil, Abstract No. 86-090761 Derwent Publications Ltd., London, GB. for JP-A-61 036206 (Kanebo KKK), Feb. 20, 1986.

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