Film-coated tablet for improved upper gastrointestinal tract saf

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Particulate form

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424451, 424456, 424457, 424461, 424464, 424468, 424474, 424475, 424486, 424489, 514108, 514960, 514961, 514962, 514963, 514964, A61K 916, A61K 950

Patent

active

061655139

ABSTRACT:
A novel oral dosage to be delivered to the stomach comprising a safe and effective amount of an active ingredient selected from the group consisting of emepronium bromidebromide, doxycycline, and other tetracyclines/antibiotics, iron preparations, quinidine, nonsteroidal anti-inflammatory drugs, alprenolol, ascorbic acid, captopril, theophylline, zidovoudine (AZT), bisphosphonates and mixtures thereof and pharmaceutically-acceptable excipients, wherein said oral dosage form is a generally oval form and film coated to facilitate rapid esophageal transit and avoid irritation in the mouth, buccal cavity, pharynx, and esophagus.

REFERENCES:
patent: 4302440 (1981-11-01), John et al.
patent: 5096717 (1992-03-01), Wirth et al.
patent: 5146730 (1992-09-01), Sadek et al.
patent: 5431920 (1995-07-01), Bechard
patent: 5622721 (1997-04-01), Dansereau et al.
patent: 5658589 (1997-08-01), Parekh et al.
Seitz, J.A., Mehta, S.P., Yeager, J.L., "Table Coating", The Theory and Practice of Industrial Pharmacy, 3.sup.rd Edition, pp. 346-373, (1986).

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