Filled gelatin capsules

Details Filled gelatin capsules Filled gelatin capsules

1997-03-06

1999-02-23

Levy, Neil S.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

424408, 514962, A61K 948

Patent

active

058741062

ABSTRACT:
Disclosed is a method of reducing crosslinking in gelatin capsules wherein an amino acid and a carboxylic acid are incorporated into the capsule fill, as well as filled gelatin capsules that utilize the disclosed method. The inventive method is especially useful for pharmaceutical formulations which include hydrochlorothiazide, triamterene, gemfibrozil, chloramphenicol, etodolac, piroxicam, nifedipine, tetracycline, diphenhydramine, hydroflumethiazide and rifampin, or a combination thereof as active ingredient.

REFERENCES:
patent: 2467715 (1949-04-01), White
patent: 2519487 (1950-08-01), Macek
patent: 4255413 (1981-03-01), Rattle et al.
patent: 5186944 (1993-02-01), Ishii et al.
patent: 5405616 (1995-04-01), Wunderlich et al.
patent: 5620704 (1997-04-01), Cade et al.
Patent Abstracts of Japan, vol. 8, No. 1261 (C-228)--13 Jun. 1984 of JP 57152080.
Patent Abstracts of Japan, vol. 13, No. 3 (C-557)--1 Jun. 1989 of JP63215641.
J.T. Carstensen & C.T. Rhodes; Drug Development & Industrial Pharmacy, 19(20), 2709-2712 (1993).
K.S. Murthy, R.G. Reisch, Jr., & M.B. Fawzi; Pharmaceutical Technology, 53-58, (Jun. 1989) pp. 53-56, 58.
K.S. Murthy, N.A. Enders, & M.B. Fawzi: Pharmaceutical Technology, 72-85 (Mar. 1989), pp. 72, 75-76, 78-79, 83-85.
L. Chafetz: Journal of Pharmaceutical Sciences, vol. 73, No. 8, (Aug. 1984) pp. 1186-1187.
G.A. Digenis, T.B. Gold & V.P. Shah; Journal of Pharmaceutical Sciences, vol. 83, No. 7, (Jul. 1994).
C.M. Marks, et al.; Food Technology, vol. 22, 1433, (Nov. 1968).

Affiliated with

Also associated with

Rating

Filled gelatin capsules does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Filled gelatin capsules, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Filled gelatin capsules will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-304366