Filariid nematode cysteine protease proteins, nucleic acid molec

Details Filariid nematode cysteine protease proteins, nucleic acid molec Filariid nematode cysteine protease proteins, nucleic acid molec

1995-06-07

1998-08-18

Sisson, Bradley L.

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

4353201, 536 231, 536 235, 935 1, 935 22, 935 66, C12N 120

Patent

active

057957681

ABSTRACT:
The present invention provides for filariid nematode cysteine protease proteins; to filariid nematode cysteine protease nucleic acid molecules, in particular, Dirofilaria immitis L3 larval cysteine protease nucleic acid molecules and Onchocerca volvulus L3 larval cysteine protease nucleic acid molecules; to antibodies raised against such proteins, and to compounds that inhibit filariid nematode cysteine protease activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies and/or inhibitors. The present invention also includes therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitors, and the use of such compositions to protect an animal from disease caused by parasitic helminths.

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