Field-free electrospray nebulizer

Details Field-free electrospray nebulizer Field-free electrospray nebulizer

2011-06-14

2011-06-14

Souw, Bernard E (Department: 2881)

Radiant energy

Radiant energy generation and sources

C250S281000, C250S282000, C250S286000, C250S503100, C250S505100

Reexamination Certificate

active

07960711

ABSTRACT:
An improved electrospray ion source for increasing the current generated from the electrospray process and of the type having a needle (10), a counter-electrode (20), a saddle or outer electrode (30), and concurrent flow of gas (92). A method and device is disclosed that utilizes a controlled electrospray nebulizer where an aerosol comprised of charged droplets and gas-phase ions is sprayed into a field-free or near field-free desolvation or reaction region (120). This process results in the production and ultimate destination of charged aerosols and gas-phase ions in field-free or near field-free regions (120, 201, 210, 240, 340) where they can be directed towards and into a sampling aperture or tube; directed into a reaction region resulting in to the production of reaction products; or directed and deposited on surfaces resulting in the production of desorbed products by means of a concurrent flow of gas or nebulizing gas (92, 94, 96), a potential difference between the regions of production and destination, counter-current flow of gas, or a combination thereof. The method is useful for increasing the detection of analytes in solutions that are electrosprayed and analyzed with mass spectrometry.

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