Fiducial marker for correlating images

Details Fiducial marker for correlating images Fiducial marker for correlating images

2011-06-21

2011-06-21

Glick, Edward J (Department: 2882)

X-ray or gamma ray systems or devices

Auxiliary data acquisition or recording

Distance or dimension marker

C378S044000, C378S063000

Reexamination Certificate

active

07965820

ABSTRACT:
The invention relates to a fiducial marker having a marking grid that is used to correlate and view images produced by different imaging modalities or different imaging and viewing modalities. More specifically, the invention relates to the fiducial marking grid that has a grid pattern for producing either a viewing image and/or a first analytical image that can be overlaid with at least one other second analytical image in order to view a light path or to image different imaging modalities. Depending on the analysis, the grid pattern has a single layer of a certain thickness or at least two layers of certain thicknesses. In either case, the grid pattern is imageable by each imaging or viewing modality used in the analysis. Further, when viewing a light path, the light path of the analytical modality cannot be visualized by viewing modality (e.g., a light microscope objective). By correlating these images, the ability to analyze a thin sample that is, for example, biological in nature but yet contains trace metal ions is enhanced. Specifically, it is desired to analyze both the organic matter of the biological sample and the trace metal ions contained within the biological sample without adding or using extrinsic labels or stains.

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Miller et al., et al., “A new sample substrate for imaging and correlating organic and trace metal composition in biological cells and tissues”, Anal. Bioanal. Chem., 387(5):1705-15 (2007) (e-published Nov. 18, 2006).

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