Fibrous matrix for in vitro cell cultivation

Chemistry: molecular biology and microbiology – Spore forming or isolating process

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43524024, 435240243, 43524025, 435179, 435180, C12N 500, C12N 506, C12N 1108, C12N 1112

Patent

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052664767

ABSTRACT:
There is provided a matrix and cultivation system for anchorage dependent cells. The matrix is characterized by a substantially increased available effective surface area for cell attachment which is attained by resorting to the use of a fiber network or open-pore foams with suitable pore size. Attachment of the cells can be enhanced by modifying the surface of the substrate. One embodiment comprises a matrix in particle or flake form.

REFERENCES:
patent: 3941661 (1976-03-01), Noteboom
patent: 4144126 (1979-03-01), Burbidge
patent: 4546083 (1985-10-01), Meyers
patent: 4789634 (1988-12-01), Muller-Lierheim
patent: 4861714 (1989-08-01), Dean, Jr. et al.
Kruse, Jr. et al. (Eds.) Tissue Culture, 1973 Academic Press, New York, pp. 333-336, 338, 339, 377-379.
Freshney Culture of Animal Cells. 1983 Liss, Inc. N.Y. pp. 55-60.

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