Fibrous calcium pyrophosphate particles and methods of...

Details Fibrous calcium pyrophosphate particles and methods of... Fibrous calcium pyrophosphate particles and methods of...

2007-07-11

2011-12-27

Noakes, Suzanne M. (Department: 1656)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

Reexamination Certificate

active

08084060

ABSTRACT:
Fibrous calcium pyrophosphate particles with a unique fibrous nanostructure are disclosed. The invention includes a composition, comprising fibrous particles, wherein the fibrous particles include fibers and the fibers include calcium and pyrophosphate. Also included are methods for making calcium pyrophosphate particles wherein solutions of calcium salt and pyrophosphate salt are combined to form the particles. Pharmaceutical compositions and methods for treating a patent using the disclosed particles are also described.

REFERENCES:
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patent: WO 02/41844 (2002-05-01), None
Ishikawa et al. J of Bone and Joint Surgery, 1989, vol. 71, pp. 875-886.
O. Masala et al., Modeling the formation of granules: the influence of manganese ions on calcium pyrophosphate precipitates, Inorganica Chimica Acta, 2002, vol. 339, pp. 366-372.
Liu, et al. “Creating New Supramolecular Materials by Architecture of Three-Dimensional Nanocrystal Fiber Networks,” J. Am. Chem Soc. 2002, 124, 15055-15063.
Shinozaki et al., “Calcium Pyrophosphate Dihydrate (CPPD) Crystal Dissolution by Alkaline-Phosphatase-Interaction of Alkaline-Phosphatase on Cppd Crystals,” J. of Rheumatology, 22(1) 117 (1995).
Remington: the Science and Practice of Pharmacy, 19th edition, Mack Publishing Co., Easton PA (1995).
Masala et al., “Formation of Spherical Granules of Calcium Pyrophosphate,” Crystal Growth and Design, vol. 3, 431 (2003).

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