Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1994-06-01
1996-05-07
Fay, Zohreh
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514912, A61K 3710
Patent
active
055146473
ABSTRACT:
A stable and soluble multi-dose ophthalmic solution is disclosed. The solution contains fibronectin, an amino acid, a sugar, and a lower alkyl p-hydroxybenzoate. A method treatment of ophthalmic wounds employing the ophthalmic solution, a process for preparing fibronectin for ophthalmic use, a method of lyophilizing an aqueous solution of fibronectin free of albumin, a method for inhibiting bacterial growth in an ophthalmic solution while preserving the cellular adhesion and wound healing activities of fibronectin, and a method of treatment of ophthalmic wounds administering a wound-healing accelerator solution are also disclosed.
REFERENCES:
patent: 4565651 (1986-01-01), Ohmura
patent: 4740498 (1988-04-01), Hirao et al.
patent: 4837019 (1989-06-01), Georgalas et al.
patent: 4841023 (1989-06-01), Horowitz
Stern, M. E. et al., "The Effects of Human Recombinant Epidermal Growth Factor on Epithelial Wound Healing," Healing Processes in the Cornea, pp. 69-77 (C. E. Crosson and H. E. Kaufman, Eds.) (1989).
Countois, Y. et al., 181 C R. Soc. Biol., pp. 491-495 (1987).
Horowitz, B. and Chang, N. Y., "Preparation of Fibronectin for Therapeutic Administration", Fibronectin, pp. 441-455 (Deane S. Mosher, Ed.) (1989).
Moses, R. et al., 18 Invest Ophthamal 103-106 (1979).
Nishida, T., et al., 102 Arch. Opthamal 455-456 (1984).
Assouline, M. et al., "Fibroblast Growth Factor Effects on Corneal Wound Healing in the Rabbit", Healing Processes in the Cornea, pp. 79-97 (C. E. Crosson and H. E. Kaufman, Eds.) (1989).
Mullen, W. et al., Survey of Ophtalmology, 17:469-483 (1973).
Nelson, J. D., et al., Am. J. of Opthal. 114:441-447 (1992).
The USP, vol. XXI, p. 1339, "General Information/Pharmaceutical Dosage Forms"1985.
Chemical Abstracts, vol. 11, No. 10, p. 368, col. 1, Shiseido Co., Ltd., "Cosmetics containing fibronectin" (Sep. 3, 1984).
Gottfried, N. S., "Alkali p-Hydroxybenzoate Esters as Pharmaceutical Preservatives", Am. J. Hosp. Pharm., 19:310-314 (1962).
Horowitz Bernard
Kawashima Yoichi
Nishimura Toyohiko
Setton Adrianne J.
Shulman Richard W.
Cave Bryan
Fay Zohreh
JCR Pharmaceuticals Co. Ltd.
New York Blood Center Inc.
Santen Pharmaceutical Co. Ltd.
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