Fibronectin binding protein polypeptides

Details Fibronectin binding protein polypeptides Fibronectin binding protein polypeptides

1995-06-02

1999-09-21

Caputa, Anthony C.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Amino acid sequence disclosed in whole or in part; or...

4242341, 4242431, 530300, 530350, 536 237, A61K 3902, A61K 39085, A61K 3800, C07K 100

Patent

active

059550783

ABSTRACT:
A monoclonal antibody (Mab), or a fragment thereof, that binds to one or more epitopes of a matrix binding protein and an isolated D1-D4 polypeptide (SEQ ID NO. 6, 7, and 8) from a Staphylococcus aureus Fbp and their use in the prevention of adhesion of bacteria, in particular gram positive bacteria, to extracellular matrix proteins on in-dwelling devices or to matrix proteins in wounds.

REFERENCES:
patent: 4578355 (1986-03-01), Rosenberg
patent: 5034515 (1991-07-01), Proctor
patent: 5440014 (1995-08-01), Hook et al.
Lazar et al (Molecular & Cellular Bio. vol. 8 No. 3, Mar. 1988 pp. 1247-1252).
Burgess et al (J. Of Cell Biology vol. III, No. 1990 pp. 2129-2138).
Salgaller et al (Cancer. Immunol. Immunother. 1994 vol. 39, pp. 105-116).
Flock et al (EMBO Journal vol. 6, No. 8, pp. 2351-2357 1987).
Eperse et al (Infection & Immunity vo. 37 No. 3, Aug. 1982 pp. 526-531).
Signas et al (PNAS vol. 86, Jan. 1989 pp. 699-703).
Johnson et al (Eur, J. Biochem. vol. 202, 1991 pp. 1041-1048).

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