Fibronectin binding protein compositions and methods of use

Details Fibronectin binding protein compositions and methods of use Fibronectin binding protein compositions and methods of use

2006-10-31

2006-10-31

Zeman, Robert A. (Department: 1645)

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Amino acid sequence disclosed in whole or in part; or...

C424S184100, C424S190100, C514S012200, C514S013800, C514S014800, C514S015800

Reexamination Certificate

active

07128912

ABSTRACT:
Disclosed are antibodies that block the binding of fibronectin protein to fibronectin. Also disclosed are site specifically-mutated and truncated peptide epitopes derived from the fnbA and fnbB genes ofStaphylococcus aureus, the fnbA and fnbB genes ofStreptococcus dysgalactiae, and the sfb gene ofStreptococcus pyogenes, and nucleic acid segments encoding these peptides and epitopes. The anti-(fibronectin binding site) antibodies, peptides and epitopes that give rise to antibodies that block the binding of fibronectin binding proteins to fibronectin, and DNA segments encoding these proteins and are of use in various screening, diagnostic and therapeutic applications including active and passive immunization and methods for the prevention of streptococcal and staphylococcal colonization in animals or humans. These DNA segments and the peptides derived therefrom are proposed to be of use directly in the preparation of vaccines and also for use as carrier proteins in vaccine formulations.

REFERENCES:
patent: WO-92/02555 (1992-02-01), None
McGavin et al., “Fibronectin Binding Determinants of the Stephylococcus aureus Fibronectin Receptor” May 5, 1991, vol. 266, No. 13, The Journal of Biological Chemistry USA.

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