Fibroblast growth factor homologous factor-1 (FHF-1) and methods

Details Fibroblast growth factor homologous factor-1 (FHF-1) and methods Fibroblast growth factor homologous factor-1 (FHF-1) and methods

1995-05-12

1997-12-02

Jones, W. Gary

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 243, 935 9, C07H 2104

Patent

active

056937750

ABSTRACT:
A novel protein, fibroblast growth factor homologous factor-1 (FHF-1), the polynucleotide sequence encoding FHF-1, and the deduced amino acid sequence are disclosed. Also disclosed are diagnostic and therapeutic methods of using the FHF-1 polypeptide and polynucleotide sequences and antibodies which specifically bind to FHF-1.

REFERENCES:
Zhan, et al., The Human FGF-5 Oncogene Encodes a Novel Protein related to Fibroblast Growth Factors, Molecular and Cellular Biology, 8(8):3487, 1988.
Miyamoto, et al., Molecular Cloning of a Novel Cytokine cDNA Encoding the Ninth Member of the Fibroblast Growth Factor Family, Which Has a Unique Secretion Property, Molecular and Cellular Biology, 13(7):4251, 1993.
Payson, et al., Cloning of two novel forms of human acidic fibroblast growth factor (aFGF) mRNA, Nucleic Acids Research, 21(3):489, 1993.
Yoshida, et al., Genomic sequence of hst, a transforming gene encoding a protein homologous to fibroblast growth factors and the int-2-encoded protein, Proc. Natl. Acad. Sci. USA, 84:7305, 1987.
Brookes, et al., The mouse homologue of hst/ k-FGF: sequence, genome organization and location relative to int-2, Nucleic Acids Research, 17(11):4037, 1989.
Iida, et al., Human hst-2 (FGF-6) oncogene: cDNA cloning and characterization, Oncogene, 7:303, 1992.
Merlo, et al., The Mouse int-2 gene Exhibits Basic Fibroblast Growth Factor Activity in a Basic Fibroblast Growth Factor-responsive Cell Line, Cell Growth & Differentiation, 1(10):463, 1990.
Davis et al. Basic Methods in Molecular Biology, pp. 51-57 Elsevier Science Publishing Co., New York, NY (1986).

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