Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Hormones – e.g. – prolactin – thymosin – growth factors – etc.
Patent
1997-06-02
1999-02-16
Ulm, John
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Hormones, e.g., prolactin, thymosin, growth factors, etc.
514 12, C07K 14475, C07K 1450, A61K 3818
Patent
active
058722262
ABSTRACT:
A novel protein, fibroblast growth factor homologous factor-1 (FHF-1), the polynucleotide sequence encoding FHF-1, and the deduced amino acid sequence are disclosed. Also disclosed are diagnostic and therapeutic methods of using the FHF-1 polypeptide and polynucleotide sequences and antibodies which specifically bind to FHF-1.
REFERENCES:
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Iida, et al., "Human hst-2 (FGF-6) oncogene: cDNA cloning and characterization", Oncogene, 7:303, 1992.
Merlo, et al., "The Mouse int-2 gene Exhibits Basic Fibroblast Growth Factor Activity in a Basic Fibroblast Growth Factor-responsive Cell Line," Cell Growth & Differentiation, 1110):463, 1990.
Miyamoto, et al., "Molecular Cloning of a Novel Cytokine cDNA Encoding the Ninth Member of the Fibroblast Growth Factor Family, Which Has a Unique Secretion Property," Molecular and Cellular Biology, 13(7):4251, 1993.
Payson, et al., "Cloning of two novel forms of human acidic fibroblast growth factor (aFGF) mRNA," Nucleic Acids Research, 21(3):489, 1993.
Yoshida, et al., Genomic sequence of hst, a transforming gene encoding a protein homologous to fibroblast growth factors and the int-2-encoded protein, Proc. Natl. Sci. USA, 84:7305, 1987.
Zahn, et al., "The Human FGF-5 Oncogene Encodes a Novel Protein related to Fibroblast Growth Factors," Molecular and Cellular Biology, 8(8):3487, 1988.
Macke Jennifer P.
Nathans Jeremy
Smallwood Philip M.
Saoud Christine
The Johns Hopkins University School of Medicine
Ulm John
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