Fibroblast growth factor conjugates

Details Fibroblast growth factor conjugates Fibroblast growth factor conjugates

1995-06-05

1997-10-21

Sayala, Chhaya D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 8, 424 945, 530350, 530370, 530399, 530402, 530409, A61K 3818

Patent

active

056796374

ABSTRACT:
The invention provides a conjugate comprising FGF or other polypeptide reactive with an FGF receptor, and a cytotoxic agent. The cytotoxic agent can be a ribosome-inactivating protein (RIP), such as saporin, although other cytotoxic agents can also be advantageously used. The cytotoxic agent can be attached to FGF through a chemical bond, or the composition can be prepared as a chimera using techniques of recombinant DNA. The conjugate can be used to treat FGF-mediated pathophysiological conditions by specifically targeting cells having FGF receptors and inhibiting proliferation of or causing death of such cells. Additionally, the conjugate can be used to target cytotoxic agents into cells having FGF receptors to inhibit the proliferation of such cells. The conjugate can be purified on an immobilized-heparin column.

REFERENCES:
patent: 5191067 (1993-03-01), Lappi et al.
patent: 5576288 (1996-11-01), Lappi et al.

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