Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Hormones – e.g. – prolactin – thymosin – growth factors – etc.
Patent
1988-11-14
1992-07-21
Moezie, F. T.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Hormones, e.g., prolactin, thymosin, growth factors, etc.
530324, 530325, 530326, 530327, 530330, C07K 704, C07K 706, C07K 708, C07K 710
Patent
active
051324083
ABSTRACT:
Antagonists to basic fibroblast growth factor, a 146 amino acid residue polypeptide, are produced. These antagonists are generally between 4 and 45 residues in length and are characterized by their ability to interact with the FGF receptor and/or inhibit and therefore modulate endothelial and other cell growth. One group of these antagonists includes the four residue sequence which forms basic FGF(36-39), namely Pro-Asp-Gly-Arg. Another of these antagonists includes the sequence of bovine basic FGF(106-115), namely Tyr-Arg-Ser-Arg-Lys-Tyr-Ser-Ser-Trp-Tyr. These peptides are also antagonistic to acidic FGF and other members of the family of FGF peptides. They are effective to combat FGF-promoted mitosis in melanomas and the like.
REFERENCES:
patent: 4444760 (1984-04-01), Thomas, Jr.
Esch et al., Proc. Natl. Acad. Sci. USA, 82, 6507-6511, 1985.
Gaspodarowicz et al., Biochem. Biophys. Res. Commun., 128, No. 2, 554-562 (1985).
Esch et al., Biochem. Biophys. Res. Commun., 133, No. 2, 554-562, 1985.
Baird Andrew J.
Ling Nicholas C.
Moezie F. T.
The Salk Institute for Biological Studies
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