Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1995-06-05
1998-06-30
Elliott, George C.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
43525233, 4353201, 435348, 4353651, 536 2351, C12P 2100, C12N 510, C12N 1516, C12N 1563
Patent
active
057732523
ABSTRACT:
Disclosed is a human Fibroblast growth factor-15 polypeptide and DNA(RNA) encoding such polypeptide. Also provided is a procedure for producing such polypeptide by recombinant techniques. Also disclosed are methods for utilizing such polypeptide for stimulating re-vascularization, for treating wounds and prevent neuronal damage. Antagonists against such polypeptides and their use as a therapeutic to prevent abnormal cellular proliferation, hyper-vascular diseases and epithelial lens cell proliferation are also disclosed. Diagnostic methods for detecting mutations in the coding sequence and alterations in the concentration of the polypeptides in a sample derived from a host are also disclosed.
REFERENCES:
Origins of Human Cancer: A Comprehensive Review--Cold Spring Harbor, New York, pp. 675-683. (Sept. 1990).
Progress in Growth Factor Research, vol. 1, pp. 207-235. (1989).
Greene John M.
Rosen Craig A.
Elliott George C.
Human Genome Sciences Inc.
Mullins J. G.
Olstein Elliot
Schwartzman Robert
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