Fibroblast growth factor 15

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

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43525233, 4353201, 435348, 4353651, 536 2351, C12P 2100, C12N 510, C12N 1516, C12N 1563

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active

057732523

ABSTRACT:
Disclosed is a human Fibroblast growth factor-15 polypeptide and DNA(RNA) encoding such polypeptide. Also provided is a procedure for producing such polypeptide by recombinant techniques. Also disclosed are methods for utilizing such polypeptide for stimulating re-vascularization, for treating wounds and prevent neuronal damage. Antagonists against such polypeptides and their use as a therapeutic to prevent abnormal cellular proliferation, hyper-vascular diseases and epithelial lens cell proliferation are also disclosed. Diagnostic methods for detecting mutations in the coding sequence and alterations in the concentration of the polypeptides in a sample derived from a host are also disclosed.

REFERENCES:
Origins of Human Cancer: A Comprehensive Review--Cold Spring Harbor, New York, pp. 675-683. (Sept. 1990).
Progress in Growth Factor Research, vol. 1, pp. 207-235. (1989).

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