Fibroblast growth factor 15

Details Fibroblast growth factor 15 Fibroblast growth factor 15

1998-06-23

2000-01-11

Schwartzman, Robert A.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

530324, 530350, C12P 2102, C07K 1450

Patent

active

060134771

ABSTRACT:
Disclosed is a human Fibroblast growth factor-15 polypeptide and DNA(RNA) encoding such polypeptide. Also provided is a procedure for producing such polypeptide by recombinant techniques. Also disclosed are methods for utilizing such polypeptide for stimulating re-vascularization, for treating wounds and prevent neuronal damage. Antagonists against such polypeptides and their use as a therapeutic to prevent abnormal cellular proliferation, hyper-vascular diseases and epithelial lens cell proliferation are also disclosed. Diagnostic methods for detecting mutations in the coding sequence and alterations in the concentration of the polypeptides in a sample derived from a host are also disclosed.

REFERENCES:
patent: 5773252 (1998-06-01), Greene et al.
Smallwood, P. M., et al., Proc. Natl. Acad. Sci., vol. 93:9850-9857 (1996).
Auffray et al. "Image: Molecular integration of the analysis of the human genome and its expression," C.R. Acad. Sci. III, Sci. Vie 318(2):263-272 (1995); assigned Genbank Accession No. Z45811; source: human, published on Nov. 14, 1994, and accessed on May 5, 1998.
Baird et al. (1988) PNAS 85:2324-2328.
Terada et al., Origins of Human Cancer, J. Brugge (Ed.) Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York, 1991, pp. 675-683.
Klagsbrun, M. (1989) Progress in Growth Factor Research 1:207-235.

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