Fibroblast growth factor 13

Details Fibroblast growth factor 13 Fibroblast growth factor 13

1995-06-05

1998-03-17

Allen, Marianne P.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

536 2351, 4353201, 435325, C12N 1519, C12N 1512

Patent

active

057285462

ABSTRACT:
Disclosed is a human Fibroblast growth factor-13 polypeptide and DNA(RNA) encoding such polypeptide. Also provided is a procedure for producing such polypeptide by recombinant techniques. Also disclosed are methods for utilizing such polypeptide for promoting wound healing for example as a result of burns and ulcers, to prevent neuronal damage associated with stroke and due to neuronal disorders and promote neuronal growth, and to prevent skin aging and hair loss, to stimulate anglogenesis, mesodermal induction in early embryos and limb regeneration. Antagonists against such polypeptides and their use as a therapeutic to prevent abnormal cellular proliferation, hyper-vascular diseases and epithelial lens cell proliferation are also disclosed. Diagnostic methods for detecting mutations in the coding sequence and alterations in the concentration of the polypeptides in a sample derived from a host are also disclosed.

REFERENCES:
Klagsbrun, M., Progress in Growth Factor Research, vol. 1, issued 1989, pp. 207-235, cited in co-pending application, 1989.

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