Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1995-06-05
1998-06-09
Allen, Marianne P.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
536 235, 4353201, 435325, 4352523, C12N 1512
Patent
active
057632146
ABSTRACT:
Disclosed is a human Fibroblast growth factor-11 polypeptide and DNA(RNA) encoding such polypeptide. Also provided is a procedure for producing such polypeptide by recombinant techniques. Also disclosed are methods for utilizing such polypeptide for promoting wound healing for example as a result of burns and ulcers, to prevent neuronal damage associated with stroke and due to neuronal disorders and promote neuronal growth, and to prevent skin aging and hair loss, to stimulate angiogenesis, mesodermal induction in early embryos and limb regeneration. Antagonists against such polypeptides and their use as a therapeutic to prevent abnormal cellular proliferation, hyper-vascular diseases and epithelial lens cell proliferation are also disclosed. Diagnostic methods for detecting mutations in the coding sequence and alterations in the concentration of the polypeptides in a sample derived from a host are also disclosed.
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Basilico, et al; Advances In Cancer Research, 1992; 59:115-165.
Aaronson, et al, Keratinocyte Growth Factor, 1992,; 62-77.
Jaye et al, Science, 1986; 233:541-545.
Barinaga, Science, 1994; 264:772-774.
Hu Jing-Shan
Rosen Craig A.
Allen Marianne P.
Human Genome Sciences Inc.
Mullins J. G.
Olstein Elliot M.
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