Fibrinophilic urokinase complex

Details Fibrinophilic urokinase complex Fibrinophilic urokinase complex

1989-09-05

1991-04-02

Stone, Jacqueline

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Stabilized enzymes or enzymes complexed with nonenzyme

424 9463, 424543, 435215, 435226, 435188, A61K 37547, C12N 900

Patent

active

050046098

ABSTRACT:
This invention discloses a fibrinophilic urokinase complex which is a complex of urokinase with a urokinase inhibitor or tissue activator inhibitor and has a molecular weight of 97,500.+-.3,000 and a method for the production of this fibrinophilic urokinase complex from urine. The urokinase complex can be used, as a thombolytic agent exhibiting an outstanding ability to dissolve thrombus.

REFERENCES:
patent: 4258030 (1981-03-01), Sasaki et al.
Stump et al, J. Biol. Chem., vol. 216 (3), 1-25-86, pp. 1267-1273.
Kruithof et al, Blood, vol. 64(4), Oct. 1984, pp. 907-913.
Astedt et al, cited in Biol. Abstracts, 80(3), 19105, 1985.
Cieplak et al, Thromb. Haemostasis 53(1), 1958, pp. 36-41.
Clemmenson et al, Protides Biol. Fluids, Proc. Colloq. 1975 (pub. 1976), 23, pp. 39-42.
Sumi et al, cited in Chem. Abstracts 96(3):165202h, 1982.

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