Fibrinolytic protein and production method thereof

Details Fibrinolytic protein and production method thereof Fibrinolytic protein and production method thereof

1993-05-24

1998-05-12

Sayala, Chhaya D.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

530416, 530417, 435212, 435217, 435222, 424 941, 424 943, 424 9464, C07K 1432, C07K 120

Patent

active

057506507

ABSTRACT:
A novel peptide having molecular weight of 31,000 (SDS-PAGE) is obtained from aqueous extract of Natto or the culture of Bacillus natto by purification procedures including alcohol fractionation and/or salting out and hydrophobic chromatography, and the physicochemical properties, including the amino acid sequence, of the peptide are determined.
The peptide is active in fibrinolysis, exhibits strong thrombolytic activity by oral administration and is useful as an oral thrombolytic agent.

REFERENCES:
patent: 4110477 (1978-08-01), Naruse et al.
patent: 5260206 (1993-11-01), Aretz et al.
Abstracts of Hiratani et al., Jap Pat No. J01180834, dated Jul., 1989, from Databases `World Pat Index` and `JAP10`.
Abstracts of Morimoto N (assignee), JAP Pat No. J 6 1162184, dated Jun., 1986, from Databases `World Pat Index` and `JAP10`.
Sumi et al., Amino Acid Sequence from Database `PIR`, for Fibrinolysis Enzyme Natto Kinase, Accession #JS0517, dated Mar. 1992.
Sumi, H, Amino Acid Seq, from Database `PIR` for Fibrinolysis Enzyme Natto Kinase, Accession #JS0601 dated Dec. 1991.
Kurihara et al., Amino Acid Sequence form Database `PIR`, for Bacillus Subtilis, (Amylosacchariticus), Accession #A00971, dated Dec. 1986.
Harris, E. L. V. et al, "Protein purification and methods", IRL Press, 1989, pp. 51-66, 221-230.
Chem. Abstracts, vol. 112, 1990, 132477b, Hiratani et al, effective date 18 Jul. 1989.
Chem. Abstracts, vol. 103, 1985, 173826x, Sumi et al.
Hames, in Gel Electrophoresis of Proteins, Chap. 1, IRL Press, Eds. Hames et al, 1981.

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