Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing – Hydrolases
Patent
1991-08-09
1993-11-09
Robinson, Douglas W.
Drug, bio-affecting and body treating compositions
Enzyme or coenzyme containing
Hydrolases
435219, A61K 3754
Patent
active
052600602
ABSTRACT:
Novel fibrinolytic zinc metalloproteinases exhibiting direct fibrinolytic activity in plasminogen free systems, no detectable plasminogen activation activity in vitro, and no observable systemic toxicity in vivo as exemplified by the absence of hemorrhagic activity, characterized by peptide bond cleavage specificities which are markedly different from those of the heretofore identified metalloproteinases. Several of the enzymes are further characterized by substantially reduced proteolytic activity (as measured by azocaseinolytic activity in vitro) relative to A.c.contortrix fibrolase. The novel fibrinolytic enzymes with reduced proteolytic activity generally exhibit levels of proteolytic activity less than about 70% of that exhibited by a fibrinolytic enzyme having the activity profile of the enzyme as isolated from A.c.contortrix venom.
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Willis et al., "Purification and Biochemical Characterization of Atroxase, a Nonhemorrhagic Fibrinolytic Protease From Western Diamondback Rattlesnake Venom", Biochemistry, 1988, 27, 4769-4777.
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Markland, Jr. Francis S.
Retzios Anastassios D.
Robinson Douglas W.
University of Southern California
Witz Jean C.
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