Fibrinolytic enzyme from snake vernom

Details Fibrinolytic enzyme from snake vernom Fibrinolytic enzyme from snake vernom

1984-01-06

1986-09-09

Shapiro, Lionel M.

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

424 98, 435212, 435217, 435226, A61K 3754, A61K 3558, C12N 948, C12N 968, C12N 964

Patent

active

046108793

ABSTRACT:
A protease moiety having direct fibrinolytic activity which is useful in thrombolytic therapy is isolated from snake venom and shown to comprise a metalloproteinase having a molecular weight of from 25 to 27 kd and an isoelectric point of about 6.5 to 7.0. The moiety is separated from venom by a series of diverse fractionation steps including molecular sieve, ion-exchange and affinity chromatography.

REFERENCES:
patent: 3879369 (1975-04-01), Nolan
patent: 4012502 (1977-03-01), Philpot, Jr.
patent: 4027012 (1977-05-01), Antonini
patent: 4350625 (1982-09-01), Abe
patent: 4461833 (1984-07-01), Gordon
Methods in Enzymology vol. 80, pp. 275-285, (1981).

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