Drug – bio-affecting and body treating compositions – Lymphokine
Patent
1987-12-21
1989-10-10
Rollins, John W.
Drug, bio-affecting and body treating compositions
Lymphokine
424 9, 436548, A61K 31745, A61K 4900
Patent
active
048730831
ABSTRACT:
In accordance with the present invention, a composition is provided that is effective in dissolving blood clots and reestablishing and maintaining blood flow through thrombosed coronary or other blood vessels. The fibrinolytic composition of the present invention comprises an enzyme, such as streptokinase, urokinase, tissue plasminogen activator or other fibrinolytic enzyme, and a surface-active copolymer. The surface-active copolymer can be an ethylene oxide-propylene oxide condensation product with the following general formula:
REFERENCES:
patent: 3450502 (1969-06-01), Hymes
patent: 3577522 (1971-05-01), Hymes
patent: 3590125 (1971-06-01), Hymes
patent: 3641240 (1972-02-01), Hymes et al.
patent: 3740421 (1973-06-01), Schmolka
patent: 3956259 (1976-05-01), Garcia et al.
patent: 3980772 (1976-09-01), Ginger et al.
patent: 4073886 (1978-02-01), Kohn
patent: 4186253 (1980-01-01), Yokoyama et al.
patent: 4609546 (1986-09-01), Hiratani
Schmolka, Irving R., "A Review of Block Polymer Surfactants", Journal of the American Oil Chemists Society, 54, No. 3, pp. 11-116 (1977).
Rodeheaver, G. T., "Pluronic F-68: A Promising New Skin Wound Cleanser", Ann Emerg Med, 9:11, pp. 572-576 (1980).
Moore, A. R., et al., "Reduction of Splenic Vascular Resistance During Profusion by Pluronic F-68", Journal of Surgical Research, vol. 8, No. 12, pp. 563-566 (1968).
Benner, K. U. et al., "Cold-Induced Platelet Aggregation in Vivo and Its Inhibition by a Nonionic Surface Active Substance", Thrombosis Research, vol. 2, pp. 331-342, (1973).
Hymes, A. C., "The Influence of an Industrial Surfactant Pluronic F-68, in the Treatment of Hemorrhagic Shock", Journal of Surg. Res., vol. 11, pp. 191-197 (1971).
Hoie, J., "Effects of Pluronic F68, Poloralkol, On Vascular Resistance in Vivo", Journal of Surgical Research, vol. 11, pp. 515-517, (1971).
Grover, F. L. et al., "A Nonionic Surfactant and Blood Viscosity", Arch. Surg., vol. 106, pp. 307-310, (1973).
Grover, Frederick L. et al., "The Effect of Pluronic F-68 On Circulatory Dynamics and Renal and Carotid Artery Flow During Hemorrhagic Shock", Journal of Surgical Research, vol. 17, pp. 30-35, (1974).
Ketchum, Lynn D. et al., "Emperimental Use of Pluronic F-68 in Microvascular Surgery", Dept. of Surgery (Plastic), University of Kansas Medical Center, vol. 53, pp. 288-292, (1974).
Richard, M. N., et al., "Effect of Lysine and Wetting Agents on Activated Plasminogen Solutions", Canadian Journal of Biochemistry and Physiology, vol. 41, pp. 211-217, 1963.
Technical Bulletin entitled "Performance Chemicals" describing Pluronic Block Copolymer Surfactants.
Technical Bulletin entitled "Pluronic Block Copolymer Surfactants".
Patent Cooperation Treaty International Search Report for PTC patent application No. PCT/US87/01067, File Reference No. 197220064.
Duncan Alexander
Hunter Robert L.
Emory University
Rollins John W.
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