Fibrinolytic activity enhancer

Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing – Multienzyme complexes or mixtures of enzymes

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424 9463, 424 9464, A61K 37547

Patent

active

049960504

ABSTRACT:
A fibrinolytic activity enhancer for signal-chain pro-urokinase comprising plasminogen as an active ingredient is disclosed. The fibrinolytic activity enhancer of the present invention enhances the fibrinolytic activity of single-chain pro-urokinase without causing systemic fibrinolysis. Thus, it is highly useful in the treatment of thrombosis and obstructive diseases.

REFERENCES:
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Pannell et al., cited in Biol. Abstracts vol. 83(9), 82602(1987).
Haemostasis 18: Suppl. 1, pp. 127-138 (1988), V. V. Kakkar et al.
Haemostasis 18: Suppl. 1, pp. 139-156 (1988), V. Tilsner et al.
J. Biochem 82, 1495-1498 (1977), T. Morita et al.
J. Biol. Chem., vol. 260, No. 22, pp. 12377-12381, (1985) S. Kasai et al.

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