Fibrinolysis and fibrinogenolysis treatment

Details Fibrinolysis and fibrinogenolysis treatment Fibrinolysis and fibrinogenolysis treatment

1991-08-28

1994-02-22

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

424529, A61K 37547, A61K 37553

Patent

active

052884899

ABSTRACT:
Disclosed is a fibrinolysis and fibrinogenolysis treatment which includes parenterally introducing into the body of a human patient human plasmin in fibrinolytically and fibrinogenolytically active form at a concentration and for a time sufficient to permit fibrinolytically and fibrinogenolytically active human plasmin to reach a concentration about the site of an intravascular clot sufficient to lyse the clot and/or to reduce circulating fibrinogen levels.

REFERENCES:
patent: Re32271 (1986-10-01), Husain et al.
patent: 3950513 (1976-04-01), Jensen
patent: 4051011 (1977-09-01), Miyauchi et al.
patent: 4083961 (1978-04-01), Dussourdd'Hinterland et al.
patent: 4245051 (1981-01-01), Reich et al.
patent: 4462980 (1984-07-01), Diedrichsen et al.
patent: 4774087 (1988-09-01), Wu et al.
patent: 4929560 (1990-05-01), Edmunds et al.
Knudsen, B. S., et al., "The Journal of Biological Chemistry," vol. 261(2), Aug. 15, 1986, pp. 10765-10771.
Silverstein, R. L., et al., "The Journal of Biological Chemistry," vol. 260(18), Aug. 25, 1985, pp. 10346-10352.
Loscalzo, J.; Chest, vol. 97(4), Apr. 1990-Supplement pp. 1175-1235.
International Search Report PCT US 92/06705.
K. Reddy and C. Wagner, Studies on the Stability of Plasmin, Chemical Abstracts, vol. 98, 1983, p. 330.
K. Takagi and Y. Yabushita, Antithrombotic Preparations for Medical Use, Chemical Abstracts, vol. 104, 1986, p. 393.
Ambrus et al., The Pharmacologist, 1:57 (1959).
Amris et al., Danish Medical Bulletin, 11:146-152 (1964).
Amris et al., Scand. J. Clin. & Lab. Investigation, 15:179-188 (1963).
Amris et al., Scand. J. Clin. & Lab. Investigation, 18:1-33 (1966).
Back et al., Circulation Research, IV:440-443 (1956).
Back et al., J. Clin. Invest., 37:864-871 (1958).
Cliffton, J. Am. Geriatrics Soc., 6:118-127 (1958).
Cliffton, Annal. N.Y. Acad.Sci., 68:209-229 (1957).
Cook et al., Trends in Pharmaceutical Sciences, 11:444-451 (1990).
Dano et al., Biochim. Biophys. Acta, 566:138-151 (1979).
Duckert et al., in New Concepts in Streptokinase Dosimetry, Martin, Schoop & Hirsch, eds., Hans Huber Publishers, Bern-Stuttgart, 1978, pp. 175-178.
Edy et al., Thrombosis Research, 8:513-518 (1976).
Evans, C. H. in Biochemistry of the Lanthanides, Plenum Press, New York, pp. 85-125, 1990.
Hedner et al., Blood, 51:157-164 (1978).
Hirsh, in: New Concepts in Streptokinase Dosimetry, Martin, Schoop & Hirsch, eds. Hans Huber Publishers, Bern-Stuttgart, 1978, pp. 239-243.
Liu et al., Canadian J. Biochem., 49:1055-1061 (1971).
Marbet et al., Thromb. Haemostas., 48:187-189 (1982).
Marbet et al., Thromb. Haemostas., 48:190-195 (1982).
Marbet et al., Thromb. Haemostas., 48:196-200 (1982).
Matsuo et al., Nature, 291:590-591 (1981).
Mizutani et al., Japanese Circulation J., 51:822 (1987).
Powell et al., J. Biol. Chem., 255:5329-5335 (1980).
Shi et al., J. Biol. Chem., 263:17071-17075 (1988).
Sottrop-Jensen et al., in Progress in Chemical Fibrinolysis and Thrombolysis, vol. 3, Davidson et al., eds. Raven Press, New York, 1978, pp. 191-209.
International Search Report, PCT/US92/06703.

Affiliated with

Also associated with

Rating

Fibrinolysis and fibrinogenolysis treatment does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Fibrinolysis and fibrinogenolysis treatment, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Fibrinolysis and fibrinogenolysis treatment will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-169312