Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1990-10-10
1992-02-25
Doll, John
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
530388, 43524027, 4352402, 435 72, 436518, C07K 1528, C12N 518, G01N 33567, G01N 33543
Patent
active
050915126
ABSTRACT:
The subject invention relates to a fibrinogen-specific monoclonal antibody wherein said monoclonal antibody: (a) binds to the isolated A.alpha. chain of fibrinogen, (b) does not prolong the conversion time of fibrinogen to fibrin by thrombin, (c) binds to fibrin and (d) does not crossreact with plasmin derived fibrinogen degradation products. The subject invention also covers the use of such a monoclonal antibody in an immunoassay for the determination of plasma fibrinogen levels in vitro.
REFERENCES:
Ehrlich et al. (1983), Biochemistry, 22, 4884-4192.
Gollwitzer et al. (1986), in Fibrogen Fibrin Formation and Fibrinolysis, vol. 4, Proceedings Workshop on Fibrinogen, Apr. 2-3, 1985, London, England, pp. 4298-4302 (Lane et al. Eds.).
Zamarron et al. (1990), Thrombosis and Haemostasis, 64(1), 41-45.
Koppert et al. (1985), Blood, 66(3), 503-507.
Hoegee-de Nobel et al. (1988), Thrombosis and Haemostasis, 60(3), 415-418.
Sola, B. et al., Thrombosis Research, 29:643-653, 1983.
Francis, S. E. et al., Am. J. of Hermatology, 18:111-119, 1985.
Joshua, D. E. et al., Annual Meetings of the Hermatology Society of Australia and Australian Society of Blood Transfusion, Oct. 1983 (abstract).
Gargan Paul E.
Pleasants Julian R.
Ploplis Victoria A.
American Biogenetic Sciences Inc.
Doll John
Futrovsky Susan L.
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