Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal
Patent
1973-11-07
1976-06-29
Gotts, Lewis
Chemistry of carbon compounds
Miscellaneous organic carbon compounds
C-metal
424177, C07C10352, C08H 100, A61K 3700
Patent
active
039667014
ABSTRACT:
Fibrinogen peptide derivatives which have biological activity as anticoagulants of blood having the dipeptide moiety prolylarginine or the tripeptide moiety glycylprolylarginine, e.g., L-prolyl-L-arginine benzyl ester p-toluenesulfonate trifluoroacetate, glycyl-L-prolyl-L-arginine benzyl ester p-toluenesulfonate trifluoroacetate, N-t-butyloxycarbonyl-L-prolyl-L-arginine benzyl ester p-toluenesulfonate methanolate, N-benzyloxycarbonyl-prolyl-L-arginine benzyl ester p-toluenesulfonate methanolate and N-t-butyloxycarbonylglycol-L-prolyl-L-arginine benzyl ester p-toluenesulfonate.
REFERENCES:
patent: 3778426 (1973-12-01), Najjar
Robison: Arch. Biochem, Biophys., 122, 516-518 (1967).
Dorman et al.: "Chemistry and Biology of Peptides," J. Meienhofer, ed., Ann Arbor Science Pub., Ann Arbor, Mich., 1972, pp. v-viii, 455-459.
Cheng Roberta C.
Dorman Linneaus C.
Bjoch C. Kenneth
Gotts Lewis
Post Theodore
Suyat Reginald J.
The Dow Chemical Company
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