Fibrinogen-containing dry preparation, manufacture and use there

Details Fibrinogen-containing dry preparation, manufacture and use there Fibrinogen-containing dry preparation, manufacture and use there

1982-06-25

1984-04-17

Morris, Theodore

Package making

Methods

With contents treating

106124, 424101, 424124, 424177, 424359, 53440, 424 27, A61K 914, A61K 3514, A61K 3700

Patent

active

044426550

ABSTRACT:
A dry preparation having a foam-like and, respectively, fleece-like structure obtained by freeze-drying consists, apart from thrombin in at least catalytically active amounts, substantially of approx. 10 to 95% by weight of fibrin and approx. 5 to 90% by weight of fibrinogen. For the preparation thereof, fibrin is produced in situ in an aqueous solution containing fibrinogen and thrombin and the resultant reaction mixture is deep-frozen and lyophilized. As further constituents of the dry preparation active substances such as e.g. antibiotics, natural bone material and/or a synthetic, bone-forming substitute, glycoproteins, coagulation-conducive substances and the like and/or fibrinolysis inhibitors come into consideration. The dry preparation is provided mainly for use as a wound toilet material, as a filling material for bone cavities and/or as a supporting material for further active substances.

REFERENCES:
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patent: 3928566 (1975-12-01), Briggs et al.
patent: 4113853 (1978-09-01), Funakoshi et al.
patent: 4298598 (1981-11-01), Schwarz et al.
patent: 4362567 (1982-12-01), Schwarz
Chem. Abst. 90:101,085V, Bruhn (1979).
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Chem. Abst. 95: 225,618u, Haverich Thorac Cardiovas Surg. 1981.
Schwarz et al.-Chem. Abst. vol. 94 (1981), p. 36318q.
Schwarz et al.-Chem. Abst. vol. 94 (1981) p. 36384h.
McKendrick et al.-Chem. Abst. vol. 76 (1972) p. 17809n.

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