Fibrinogen binding peptides

Details Fibrinogen binding peptides Fibrinogen binding peptides

1996-02-02

1998-03-03

Tsang, Cecilia J.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

6 to 7 amino acid residues in defined sequence

530330, 530382, 530413, A61K 3808, C07K 704, C07K 1475

Patent

active

057235791

ABSTRACT:
Peptides which bind to fibrinogen are disclosed. These peptides have available fibrinogen binding domains having a Phe-Leu-Leu-Val or Leu-Leu-Val-Pro sequence. The preferred peptide is a 6-mer having the sequence Phe-Leu-Leu-Val-Pro-Leu (SEQ ID NO:1). A method of using these peptides in an affinity chromatography process to purify fibrinogen is described.

REFERENCES:
Poulsen, K. et al. Competitive inhibitors of renin. Biochemistry, 12(20), 3877-82 1973.
Nayersina, R. et al HLA A2 restricted cytotoxic T lymphocyte responses to multilpe hepatitis B surface antigen epitopes during hepatitis B virus infection. J. Immunol., 150(10), 4659-71 1993.
Baumann, M. et al. Molecular cloning, characterization and functional expression of therat liver interleukin 6 receptor. J. Biol. Chem. 265, 19853-19862 1990.
Laddaga, R. et al. Nucleotide sequence and expression of the mercurial-resistance operon from Stahylococcus aureus plasmid pl258. Proc. Natl. Acad. Sci. USA, 84, 5106-5110 1987.
Sugita, T. Functional murine interleukin 6 receptor with the intracisternal A particle gene product at its cytosolic domain. J. Exp. Med. 171, 2001-2009 1990.

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