Fibrin sealant delivery method

Details Fibrin sealant delivery method Fibrin sealant delivery method

1990-01-03

1993-06-15

Rosenbaum, C. Fred

Surgery

Means for introducing or removing material from body for...

Material introduced into and removed from body through...

604 54, 604 56, 604290, 606214, A61M 3100, A61M 3500

Patent

active

052193284

ABSTRACT:
The present invention relates to a method for the formulation of fibrin sealant in a single delivery system. The method involves mixing a fibrinogen/Factor XIII precipitate solution with thrombin under conditions such that thrombin clotting activity is inhibited and said mixture is applied to a body site under conditions which activate the thrombin to convert fibrinogen into fibrin sealant. A single device, syringe or container, can be used to apply the fibrin sealant formulation.

REFERENCES:
patent: 2492458 (1949-12-01), Berry
patent: 2533004 (1950-12-01), Ferry et al.
patent: 3723244 (1973-03-01), Breillatt, Jr.
patent: 4265233 (1981-05-01), Sugitachi et al.
patent: 4359049 (1982-11-01), Redl et al.
patent: 4359463 (1982-11-01), Rock
patent: 4377572 (1983-03-01), Schwarz et al.
patent: 4427651 (1984-01-01), Stroetmann
patent: 4442655 (1984-04-01), Stroetmann
patent: 4453939 (1984-06-01), Zimmerman
patent: 4627879 (1986-12-01), Rose
patent: 4631055 (1986-12-01), Redl et al.
patent: 4655211 (1987-04-01), Sakamoto et al.
patent: 4696812 (1987-09-01), Silbering et al.
patent: 4735616 (1988-04-01), Eibl et al.
patent: 4902281 (1990-02-01), Avoy
Haberli et al. (1987) Propolymers 26:27-43.
Dresdale et al., Hemostatic Effectiveness of Fibrin Glue Derived from Single-Donor Fres Frozen Plasma, Ann. Thorac. Surg., 40:385 (1985).
Lupinetti et al., Cryoprecipitate-topical thrombin gel: Initial experience in patients undergoing cardiac operations, J. Thorac. Cardiovasc. Surg., 90:502 (1985).
Carr et al., Influence of Ca2+ on the Structure of Reptilase-derived and Thrombin-derived fibrin gels, Biochem. J. 293:513 (1986).
Kaminski et al., Studies on the Mechanism of Thrombin, J. Biol. Chem. 258:10530 (1983).
Turner et al., Photochemical Activation of Acylated-Thrombin, J. Am. Chem. Soc. 109:1274-1275 (1987).
Turner et al., Photoreactivation of Irreversibly Inhibited Serine Proteases, J. Am. Chem. Soc. 110:244-250 (1988).
Porter et al., Acyl Thrombin Photochemistry: Kinetics for Deacylation of Enzyme Cinnamate Geometric Isomers, J. Am. Chem. Soc. 111:7616-7618 (1989).
Laki, The Polymerization of Proteins: the Action of Thrombin on Fibrinogen, Arch Biochem. Biophys., 32:317-324 (1951).
David E. Metzler, "Biochemistry, The Chemical Reactions of Living Cells", Academic Press, Inc. N.Y. 1977 pp. 330-331.
Arthur C. Guyton, "Physiology of the Human Body", W. B. Saunders Company, Philadelphia 1979 pp. 69-75.

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