Fibrin sealant delivery kit

Details Fibrin sealant delivery kit Fibrin sealant delivery kit

1992-03-02

1994-06-07

Rosenbaum, C. Fred

Surgery

Means for introducing or removing material from body for...

Treating material introduced into or removed from body...

604 92, 604416, 606214, A61M 3700

Patent

active

053185242

ABSTRACT:
The present invention relates to a method for the formulation of fibrin sealant in a single delivery system. The method involves mixing a fibrinogen/Factor XIII precipitate solution with thrombin under conditions such that thrombin clotting activity is inhibited and said mixture is applied to a body site under conditions which activate the thrombin to convert fibrinogen into fibrin sealant. A single device, syringe or container, can be used to apply the fibrin sealant formulation.

REFERENCES:
patent: 2193717 (1940-03-01), Faust
patent: 2492458 (1949-12-01), Bering
patent: 2533004 (1950-12-01), Ferry et al.
patent: 3723244 (1973-03-01), Breillatt, Jr.
patent: 4265233 (1981-05-01), Sugitachi et al.
patent: 4359049 (1982-11-01), Redl et al.
patent: 4359463 (1982-11-01), Rock
patent: 4377572 (1983-03-01), Schwarz et al.
patent: 4427651 (1984-01-01), Stroetmann
patent: 4442655 (1984-04-01), Stroetmann
patent: 4453939 (1984-06-01), Zimmerman et al.
patent: 4627879 (1986-12-01), Rose et al.
patent: 4631055 (1986-12-01), Redl et al.
patent: 4655211 (1987-04-01), Sakamoto et al.
patent: 4668621 (1987-05-01), Doellgast
patent: 4696812 (1987-09-01), Silbering et al.
patent: 4735616 (1988-04-01), Eibl et al.
patent: 4874368 (1989-10-01), Miller et al.
patent: 4902281 (1990-02-01), Avoy
patent: 4909251 (1990-03-01), Seelich
patent: 5030215 (1991-07-01), Morse et al.
patent: 5104375 (1992-04-01), Wolf et al.
patent: 5116315 (1992-05-01), Capozzi et al.
patent: 5226877 (1993-07-01), Epstein
Nowotny et al, "Mechanical Properties of Fibrinogen-Adhesive Material", Adv. Biomaterials, 3:677-682 (1982).
Redl et al, "Background and Methods of Fibrin Sealing", Adv. Biomaterials, 3:669-676 (1982).
Dresdale et al., Hemostatic effectiveness of Fibrin Glue Derived from Single-Donor Fres Frozen Plasma, Ann. Thorac. Surg., 40:385 (1985).
Lupinetti et al., Cryoprecipitate-topical thrombin gel: Initial experience in patients undergoing cardiac operations, J. Thorac. Cardiovasc. Surg., 90:502 (1985).
Carr et al, Influence of Ca2+ on the Structure of Reptilase-derived and Thrombin-derived fibrin gels, Biochem. J., 239:513 (1986).
Kaminski et al., Studies on the Mechanism of Thrombin, J. Biol. Chem. 258:10530 (1983).
Turner et al, Photochemical Activation of Acylated-Thrombin, J. Am. Chem. Soc. 109:1274-1275 (1987).
Turner et al, Photoreactivation of Irreversibly Inhibited Serine Proteases, J. Am. Chem. Soc. 110:244-250 (1988).
Porter et al, Acyl Thrombin Photochemistry: Kinetics for Deacylation of Enzyme Cinnamate Geometric Isomers, J. Am. Chem. Soc. 111:7616-7618 (1989).
Laki, The Polymerization of Proteins: the Action of Thrombin on Fibrinogen, Arch Biochem, Biophys., 32:317-324 (1951).
Haberli et al, (1987) Biopolymers 26:27-43.
David E. Metzler, "Biochemistry, The Chemical Reactions of Living Cells", Academic Press, Inc. N.Y. 1977, pp. 330-331.
Arthur C. Guyton, "Physiology of the Human Body", W. B. Saunders Company, Philadelphia 1979 pp. 69-75.

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