Prosthesis (i.e. – artificial body members) – parts thereof – or ai – Implantable prosthesis
Patent
1996-11-07
1997-12-02
Weiss, John G.
Prosthesis (i.e., artificial body members), parts thereof, or ai
Implantable prosthesis
128898, 600 36, 435180, 424 9464, 427 224, 427 225, 427 226, 427 228, 427 23, 427 231, 623 1, 623 2, 623 12, 623 66, A61F 202, A61K 37547
Patent
active
056930984
ABSTRACT:
Methods for coating a prosthetic surface with anti-thrombogenic, or anti-coagulant, proteins are disclosed. The methods involve contacting a surface of a prosthetic material with a composition containing multimers of fibrin degradation products. These multimers, preferably D-dimers, have cross-linked D-domains. The methods of the invention are useful for providing an anti-thrombogenic coating on prosthetic implants which are exposed to a patient's blood after implantation, for example vascular grafts and artificial heart valves.
REFERENCES:
patent: 5204447 (1993-04-01), Bishop et al.
patent: 5230693 (1993-07-01), Williams et al.
patent: 5272074 (1993-12-01), Rubens
patent: 5324647 (1994-06-01), Rubens et al.
McManama et al., "Platelet Aggregation by Fibrinogen Polymers Crosslinked Across the E Domain," Blood, 363-371 (1986).
Lindblad et al., "Endothelial Cell Seeding Efficiency onto Expanded Polytetrafluorethylene Grafts with Different Coatings," Acta. Chir. Scand. 152 (1986).
Anderson et al., "In Vitro Endothelialization of Small-Caliber Vascular Grafts," Surgery, 577-586 (1987).
Zilla et al., "Endothelial Cell Seeding of Polytetrafluoroethylene Vascular Grafts in Human: A Preliminary Report," J. Vas. Sur., 535-541 (1987).
Voegel et al., "Thermal Desorption Spectrometry of Fibrinogen," Colloieds and Surfaces, 134-144 (1987).
Kaehler et al., "Precoating Substrate and Surface Configuration Determine Adherence and Spreading of Seeded Endothelial Cells on Polytetrafluoroethylene Grafts," J. Vas. Sur., 535-541 (1989).
Marzec et al., "Inhibition of Thrombus Formation In Vivo by Novem Antiplatelet Agent," Arteriosclerosis, 367-371 (1989).
Leseche et al., "Prelining of Polytetrafluoroethylene Grafts with Cultured Human Endothelial Cells Isolated from Varicose Veins," Surgery, pp. 36-45 (1989).
Fasol et al., "Allogenic Multidonor In Vitro Endothelialization of Small Diameter PTFE Grafts in Baboons," Vascular Surgery, 64-71 (1991).
Li et al., "Precoating Expanded Polytetrafluoroethylene Grafts Alters Production of Endothelial Cell-Derived Thrombomodulators," J. Vas. Sur., 1010-1017 (1991).
Mazzucotelli et al., "Endothelial Cell Seeding: Coating Dacron and Expanded Polytetrafluororthylene Vascular Grafts with a Biological Glue Allows Adhesion and Growth of Human Saphenous Vein Endothelial Cells," J. Artificial Organs, 482-490 (1991).
Hormann et al., "Immobilization of Soluble Fibrin on Factor XIIIa-Coated Polystyrene Beads Mediated by N-Terminal Fibronectin Fragments," Biol. Chem. (1991).
Soldani et al., "Bioartificial Polymeric Materials Obtained from Blends of Synthetic Polymers with Fibrin and Collagen," Intl. J. Art. Organs, 295-303 (1991).
Kadletz et al., "Implantation of In Vitro Endothelialized Polytetrafluorothylene Grafts in Human Beings," J. Thor. Cardio. Sur., 736-742 (1992).
Rubens et al., "The Effect of Antithrombin III-Independent Thrombin Inhibitors and Heparin on Fibrin Accretion onto Fibrin-Coated Polyethylene," Thrombosis and Haemostasis, 130-134 (1993).
Rubin et al., "Platelet Interactions with the Vessel Wall and Prosthetic Grafts," Basic Science, 200-207 (1993).
Robson et al., "Fibrin Degradation Product D-Dimer Induces the Synthesis and Release of Biologically Active IL-1.beta. IL-6 and Plasminogen Activator Inhibitors from Monocytes in Vitro," Brit. J. Haematology, 322-326 (1994).
Niibori et al., "The Effect of Preclotting and Collagen Coating on Endothelializing Rate and Thrombogenesity of Dacron Grafts in the Canine Thoracic Aorta," The Journal of the Japanese Association for Thoracic Surgery, p. 515 (1994).
Giusti et al., "New Biolized Polymers for Cardiovascular Applications," pp. 476-480 (no date).
Bishop Paul D.
Rubens Fraser D.
Cuddihy Francis K.
McMaster University
Weiss John G.
ZymoGenetics Inc.
LandOfFree
Fibrin D-domain multimer prostheses and methods for their produc does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Fibrin D-domain multimer prostheses and methods for their produc, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Fibrin D-domain multimer prostheses and methods for their produc will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-797671