Prosthesis (i.e. – artificial body members) – parts thereof – or ai – Implantable prosthesis
Patent
1995-04-28
1997-03-11
Weiss, John G.
Prosthesis (i.e., artificial body members), parts thereof, or ai
Implantable prosthesis
435180, 424 9464, 427 224, 427 225, 427 226, 427 228, 427 23, 427 231, 600 36, A61F 202, A61K 37547
Patent
active
056096313
ABSTRACT:
Methods for coating a prosthetic surface with anti-thrombogenic, or anti-coagulant, proteins are disclosed. The methods involve contacting a surface of a prosthetic material with a composition containing multimers of fibrin degradation products. These multimers, preferably D-dimers, have cross-linked D-domains. The methods of the invention are useful for providing an anti-thrombogenic coating on prosthetic implants which are exposed to a patient's blood after implantation, for example vascular grafts and artificial heart valves.
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Bishop Paul D.
Rubens Fraser D.
Cuddihy Francis K.
Weiss John G.
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