Chemistry: molecular biology and microbiology – Carrier-bound or immobilized enzyme or microbial cell;... – Enzyme or microbial cell is immobilized on or in an organic...
Patent
1993-09-14
1994-06-28
Robinson, Douglas W.
Chemistry: molecular biology and microbiology
Carrier-bound or immobilized enzyme or microbial cell;...
Enzyme or microbial cell is immobilized on or in an organic...
424 4464, 427 2, 436 8, 600 36, C12N 1108, A61K 37547, A01N 102
Patent
active
053246470
ABSTRACT:
Surfaces of polymeric materials are coated with a layer of thermally denatured fibrinogen. The fibrinogen may be treated with thrombin to produce fibrin, and additional fibrinogen and factor XIII added to produce a cross-linked fibrin coating. The resulting coated surface is stable, anti-thrombotic and resistant to platelet adhesion. Polymeric materials coated in this way are useful in constructing vascular grafts and prosthetic devices, and provide test systems useful in the study of thrombogenesis.
REFERENCES:
patent: 4167045 (1979-09-01), Sawyer
patent: 4273873 (1981-06-01), Sugitachi et al.
patent: 4534069 (1985-08-01), Kelman
patent: 4627879 (1986-12-01), Rose et al.
patent: 5131907 (1992-07-01), Williams et al.
patent: 5171261 (1992-12-01), Noishiki et al.
patent: 5230693 (1993-07-01), Williams et al.
patent: 5266476 (1993-11-01), Sussman et al.
Noishiki, Y., et al., "The Journal of Thoracic and Cardiovascular Surgery," vol. 104(3), Sep. 1992, p. 5A, 770-778.
Leseche, G., et al., "Surgery", vol. 105(1), Jan. 1989, pp. 36-45.
Zilla, P., et al., "Journal of Vascular Surgery," vol. 6(6), Dec. 1987, p. 5A, 535-541.
Fasol, R., et al., "Vascular Surgery," vol. 25(1), Jan./Feb. 1991, pp. 64-71.
Tizian, C., et al., "Thorac. Cardiovasc. Surgeon," vol. 28, 1980, pp. 273-276.
Anderson et al., Surg. 101:577-586, 1987.
Voegel et al., Colloids and Surfaces 25: 139-144, 1987.
Schwartz et al., J. Biol. Chem. 248: 1395-1407, 1973.
Giusti et al., Life Support Syst., 3(Suppl. 1, Proc.-Eur. Soc. Artif. Organs) 476-480, 1986.
Obara et al., FEBS Lett. 213: 261-264, 1987.
Yamada, Cur. Opin. Cell. Biol. 1: 956-963, 1989.
Mosquera et al., Br. J. Surg. 78: 656-660, 1991.
Budd et al., Br. J. Surg. 76: 1259-1261, 1989.
Rupnick et al., J. Vasc. Surg. 9: 788-795, 1989.
Kaehler et al., J. Vasc. Surg. 9: 535-541, 1989.
Lindblad et al., Acta Chirurg. Scand. 152: 653-656, 1986.
Mazzucotelli et al., Int. J. Artif. Organs 14: 482-490, 1991.
Kent et al., Trans. Am. Soc. Artif. Intern. Organs 34: 578-580, 1988.
Bishop Paul D.
Rubens Fraser D.
Larson Kristin
McMaster University
Parker Gary E.
Robinson Douglas W.
ZymoGenetics Inc.
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