Fibrin adhesive granulate and method for its preparation

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Reexamination Certificate

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Reexamination Certificate

active

07572769

ABSTRACT:
The invention relates to a flowable fibrin adhesive granulate containing thrombin, Factor XIII, fibrinogen, and a calcium salt in the form of granules with a particle size of more than 50 μm to 1000 μm. Said granulate is useful for the healing of wounds in surgery, tissue therapy and/or as supporting material for biological factors. The invention also relates to an effervescent granulate and an effervescent powder for producing a foam that is suitable for hemostasis. The invention further relates to preparations to arrest bleeding containing a non-woven fabric for wounds consisting of a biodegradable supporting material that is coated with a fibrin glue granulate mixture or mixed granulate.

REFERENCES:
patent: 4427651 (1984-01-01), Stroetmann
patent: 4453939 (1984-06-01), Zimmerman et al.
patent: 6596318 (2003-07-01), Prasch et al.
patent: 2002/0037323 (2002-03-01), Prasch et al.
patent: 2003/0143518 (2003-07-01), Luck et al.
patent: 44 41 167 (1996-03-01), None
patent: A-100 12 732 (2001-09-01), None
patent: 0 792 188 (1994-09-01), None
patent: WO 92/22312 (1992-12-01), None
patent: WO 96/22115 (1996-07-01), None
patent: WO 96/29990 (1996-10-01), None
patent: WO 97/28832 (1997-08-01), None
patent: WO 97/44015 (1997-11-01), None
patent: WO 99/15637 (1999-04-01), None
Abstract of EP 0 792 188 dated Sep. 3, 1997, from Esp@cenet Database.
English-language translation of DE 44 41 167 C1 (Mar. 14, 1990).
English-language translation of German Patent Application No. DE-A-10012732 (Sep. 20, 2001).
Decision dated Dec. 18, 2002, from the German Patent Office in case No. 198 49 589.7-45.
Chabbat, J., et al., “Properties of a new fibrin glue stable in liquid state,” Thrombosis Research, 76(6):525-533 (1994).
De laco, PierAndrea, et al., “Fibrin sealant in laparoscopic adhesion prevention in the rabbit uterine horn model,” Fertility and Sterility, 62(2):400-404 (1994).
Evrard, V.A.C., et al., “Peritoneal healing after fibrin glue application: a comparative study in a rat model,” Human Reproduction, 11(9):1877-1880 (1996).
Gauwerky, J.F.H., et al., “The effect of fibrin glue and peritoneal grafts in the prevention of intraperitonael adhesions,” Arch. Gynecol. Obstet., 247:161-166 (1990).
Lindenberg, S., et al., “Prevention of peritoneal adhesion formation by fibrin sealant,” Annales Chirurgiae et Gynaecologiae, 73:11-13 (1984).
Moro, Hisanaga, et al., “The effect of fibrin glue on inhibition of pericardial adhesions,” The Japanese Journal of Thoracic and Cardiovascular Surgery, 47(2):79-84 (1999).
Takeuchi, Hiroyuki, et al., “Effects of fibrin glue on postsurgical adhesions after uterine or ovarian surgery in rabbits,” J. Obstet. Gynaecol. Res., 23(5):479-484 (1997).
Voight, Rudolf, et al., “Lehrbuch der pharmazeutischen technologie,” 85 0570 EPO; Verla chemie (1984).
English-language translation of Voight, Rudolf, et al., “Lehrbuch der pharmazeutischen technologie,” 85 0570 EPO; Verla chemie (1984).
Prunkard, D., et al., “Heterologous production of recominant human fibrinogen, thrombin, and factor XIII as components of completely recombinant fibrin sealants,” Thrombosis and Haemostasis 9:372 (1997).
Schuefer, Torben, et al., “Control of fluidized bed granulation v. factors affecting granule growth,” Arch. Pharm. Chemi, Sci. Ed., 6:68-82 (1978).
International Search Report for PCT/EP99/06898 (WO 00/38752) dated Dec. 21, 1999.
International Search Report for PCT/EP00/08128 (WO 00/024436) dated Jan. 25, 2000.

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