Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2005-04-12
2005-04-12
Chan, Christina (Department: 1644)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S007210, C435S326000, C530S329000
Reexamination Certificate
active
06878521
ABSTRACT:
A method of minimizing the aggregation tendencies of an amyloid forming protein is provided comprising identifying a portion of the protein that is critical to amyloid formation; and inserting a peptide at the portion. The invention also provides a peptide for insertion in an intact human kappa-IV light chain variable domain, the peptide comprising the following amino acid sequence Phe71-Thr72-Leu73-Thr74-Ile75-Ser76-Ser77(SEQ ID NO. 1) wherein the subscript numbers are the residue location points in the domain. A method for preventing amyloid formation in human kappa-IV light chain variable domain is also provided, the method comprising inserting the peptide Phe1-Thr72-Leu73-Thr74-Ile75-Ser76-Ser77(SEQ ID NO. 1) into the domain, wherein the subscript numbers indicate the residue location on the domain.
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Argon Yair
Davis David P.
Raffen Rosemarie
Stevens Fred J.
Chan Christina
Cherskov & Flaynik
Huynh Phuong
The University of Chicago
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