Optical waveguides – Optical waveguide sensor
Patent
1997-03-14
2000-02-08
Ngo, Hung N.
Optical waveguides
Optical waveguide sensor
435808, 430800, 385 38, 385147, 359900, G02B 626
Patent
active
060235403
ABSTRACT:
A microsphere-based analytic chemistry system is disclosed in which microspheres carrying different chemical functionalities may be mixed together while the ability is retained to identify the functionality on each bead using an optically interrogatable encoding scheme. An optical fiber bundle sensor is also disclosed in which the separate microspheres may be optically coupled to discrete fibers or groups of fibers within the bundle. The functionalies are encoded on the separate microspheres using fluorescent dyes and then affixed to wells etched in the end of the bundle. Thus, a single sensor may carry thousands of chemistries. Only those microspheres exhibiting reactions then need to be decoded to identify the corresponding functionality.
REFERENCES:
patent: 4499052 (1985-02-01), Fulwyer
patent: 4822746 (1989-04-01), Walt
patent: 5002867 (1991-03-01), Macevicz
patent: 5028545 (1991-07-01), Soini
patent: 5105305 (1992-04-01), Betzig et al.
patent: 5114864 (1992-05-01), Walt
patent: 5132242 (1992-07-01), Cheung
patent: 5143853 (1992-09-01), Walt et al.
patent: 5194300 (1993-03-01), Cheung
patent: 5244636 (1993-09-01), Walt et al.
patent: 5244813 (1993-09-01), Walt et al.
patent: 5250264 (1993-10-01), Walt et al.
patent: 5252494 (1993-10-01), Walt
patent: 5254477 (1993-10-01), Walt
patent: 5298741 (1994-03-01), Walt et al.
patent: 5320814 (1994-06-01), Walt et al.
patent: 5496997 (1996-03-01), Pope
patent: 5512490 (1996-04-01), Walt et al.
patent: 5565324 (1996-10-01), Still et al.
patent: 5573909 (1996-11-01), Singer et al.
patent: 5633972 (1997-05-01), Walt et al.
patent: 5690894 (1997-11-01), Pinkel et al.
E.J.A.Pope, "Fiber Optic Chemical Microsensors Employing Optically Active Silica Microspheres", SPIE, v2388,p245-256 (1995).
J.I.Peterson, et al., "Fiber Optic pH Probe for Physiological Use", Anal. Chem., v52, No. 6, May 1980, p864-869.
Anonymous, "Fluorescent Microspheres", Tech Note 19, Bang Laboratories, (Fishers, IN) Feb. 1997.
L.B.Bangs, "Immunological Applications of Microspheres", The Latex Course, Bangs Laboratories (Carmel, IN) Apr. 1996.
Anonymous, "Microsphere Selection Guide", Bangs Laboratories (Fishers, IN) Sep. 1998.
Michael Karri Lynn
Walt David R.
Ngo Hung N.
Silva Robin M.
Trustees of Tufts College
LandOfFree
Fiber optic sensor with encoded microspheres does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Fiber optic sensor with encoded microspheres, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Fiber optic sensor with encoded microspheres will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1686957