Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1993-12-09
1996-02-27
Spiegel, Carol A.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 71, 435 74, 435 78, 435 79, 436501, 436518, 436527, 436546, 422 8206, 422 8211, 385 13, 385 30, 356448, C12Q 168, G01N 3353
Patent
active
054947987
ABSTRACT:
A coupled pair of fiber optic fibers are used an immunoassay device. The fibers are first coupled and then drawn down to a single mode diameter. The coupler senses output ratio change due to chemical, biochemical, bioaffinity, immunogenic-type interactions and other molecular activity occuring within the evanescent field. The fusion joint of the coupler is coated with a first immunoassay component, and then surrounded with a second immunoassay component.
REFERENCES:
patent: H1212 (1993-07-01), Thames
patent: 4447546 (1984-05-01), Hirschfeld
patent: 4634858 (1987-01-01), Gerdt
patent: 4818710 (1989-04-01), Sutherland et al.
patent: 4852967 (1989-08-01), Cook et al.
patent: 4879454 (1989-11-01), Gerdt
patent: 4909990 (1990-03-01), Block et al.
patent: 5173747 (1992-12-01), Boiarski et al.
patent: 5242797 (1993-09-01), Hirschfeld
Military Standard Glossary, Fiber Optics Dept of Defense United States of America MIL-STD-2196 (SH) 12 Jan. 1989 pp. 31, 42, 150, 153.
Vo-Dinh, T., et al., Fiber Optic Chemical Sensors and Biosensors, "Fiberoptics Immunosensors", vol. II, pp. 217-257, 1991.
Wolfbeis, Otto, Fiber Optic Chemical Sensors and Biosensors, vol. I, pp. 1-23, 1991.
Oxenford, Jeffrey L., "Development of a fiber optic chemical sensor for the monitoring of trichloroethylene in drinking water", SPIE vol. 1172 Chemical, Biochemical and Environmental Sensors pp. 108-114, 1989.
Kvasnik, Frank, et al., "Distributed chemical sensing utilising evanescent wave interactions", SPIE vol. 1172 Chemical, Biochemical, and Environmental Sensors, pp. 75-80, 1989.
Waldzak, Irene M., et al. "A sensitive Fiber Optic Immunoassay", SPIE vol. 1420 Optical Fibers in Medicine VI, pp. 2-9, 1991.
Stewart, G., et al., "Chemical sensing by evanescent field absorption: the sensitivity of optical waveguides", SPIE, vol.990 Chemical, Biochemical, and Environmental Applications of Fibers, pp. 188-195, 1988.
Heideman, Rene G., et al., "Simple interferometer for evanescent field refractive index sensing as a feasibility study for an immunosensor", Applied Optics, vol. 30, No. 12, pp. 1474-1479, Apr. 20, 1991.
Harrick, N. J., Internal Reflection Spectroscopy, pp. 27-43, 89-113, 1987.
Gerdt David W.
Herr John C.
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