Chemical apparatus and process disinfecting – deodorizing – preser – Analyzer – structured indicator – or manipulative laboratory... – Means for analyzing liquid or solid sample
Patent
1991-09-25
1993-01-05
Housel, James C.
Chemical apparatus and process disinfecting, deodorizing, preser
Analyzer, structured indicator, or manipulative laboratory...
Means for analyzing liquid or solid sample
422 8206, 356 39, 128634, G01N 2177
Patent
active
051768810
ABSTRACT:
A fiber optic-based regenerable biosensor. The biosensor is particularly suitable for use in microscale work in situ. In one embodiment, the biosensor comprises a reaction chamber disposed adjacent the distal end of a waveguide and adapted to receive therein a quantity of a sample containing an analyte. Leading into the chamber is a plurality of capillary conduits suitable for introducing into the chamber antibodies or other reagents suitable for selective interaction with a predetermined analyte. Following such interaction, the contents of the chamber may be subjected to an incident energy signal for developing fluorescence within the chamber that is detectable via the optical fiber and which is representative of the presence, i.e. concentration, of the selected analyte. Regeneration of the biosensor is accomplished by replacement of the reagents and/or the analyte, or a combination of these, at least in part via one or more of the capillary conduits. The capillary conduits extend from their respective terminal ends that are in fluid communication with the chamber, away from the chamber to respective location(s) remote from the chamber thereby permitting in situ location of the chamber and remote manipulation and/or analysis of the activity with the chamber.
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"Development of Antibody-Based Fiber-Optic sensors for Detection of a Benzo[a]-pyrene Metabolite", By Bruce J. Tomberg, Michael J. Sepaniak and Jean Pierre Alarie, Tuan Vo-Dinh and Regina M. Santella, Reprinted from Analytical Chemistry, 1988, 60, 1901.
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Sepaniak Michael J.
Vo-Dinh Tuan
Housel James C.
Snay Jeffrey R.
The University of Tennessee Research Corporation
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