FHIT proteins and nucleic acids and methods based thereon

Details FHIT proteins and nucleic acids and methods based thereon FHIT proteins and nucleic acids and methods based thereon

1996-02-09

1999-07-27

Feisee, Lila

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 71, 436503, 436507, 436547, 5303877, 5303879, 536 231, 536 235, 536 2433, G01N 33574, G01N 33567, C07H 2104, C12P 2108

Patent

active

059288841

ABSTRACT:
The present invention relates to nucleotide sequences of FHIT genes and amino acid sequences of their encoded proteins, as well as derivatives and analogs thereof, and antibodies thereto. The FHIT gene sequence is mutated in diseases involving cell overproliferation, particularly malignancies of the digestive tract. The present invention further relates to the use of FHIT genes and their encoded proteins as diagnostic and therapeutic reagents for the detection and treatment of disease states associated with cell overproliferation.

REFERENCES:
Hadaczek et al., 1996, Virchows Arch. 429:37-42.
Aburatani et al., 1995, Cytogenet. Cell Genet. 68:137-138.
Bardenheuer et al., 1994, Genomics 19:291-297.
Barsky et al., 1994, Mod. Pathol. 7:633-640.
Baxi et al., 1994, Biochem. 33:14601-14607.
Boldog, 1993, Proc. Natl. Acad. Sci. USA 90:8509-8513.
Boldog et al., 1994, Genes, Chrom. & Cancer 11:216-221.
Brauch et al., 1987, N. Eng. J. Med. 317:1109-1113.
Bullrich et al., 1995, Cytogenet. Cell Genet. 70:250-254.
Chiba et al., 1990, Oncogene 5:1603-1610.
Chung et al., 1993, Nature Genet. 5:254-258.
Cohen et al., 1979, N. Eng. J. Med. 301:592-595.
Daly et al., 1991, Genomics 9:113-119.
Daly et al., 1993, Oncogene 8:1721-1729.
Druck et al., 1995, Cancer Res. 55:5348-5353.
Ebina et al., 1994, Cancer Res. 54:2496-2503.
Fong et al., 1978, J. Natl. Canc. Inst. 61:145-150.
Fu et al., 1991, Cell 67:1047-1058.
Glover et al., 1988, Cancer Genet. Cytogenet. 31:69-73.
Gemmill et al., 1995, Cytogenet. Cell Genet. 68:137.
Gnarra et al., 1994, Nature Genet. 7:85-90.
Graphodatsky et al., 1995, Cytogenet. Cell Genet. 68:142.
Hahn et al., 1996, Science 271:350-353.
Harbour et al., 1988, Science 241:353-357.
Hibi et al., 1992, Oncogene 7:445-449.
Horio et al., 1993, Cancer Res. 53:1-4.
Huang et al., 1995, Biochem. J. 312:925-932.
Hung et al., 1995, JAMA 273:558-563.
International Union Against Cancer, 1989, "TNM classification of malignant tumors," 3rd ed., Geneva: World Health Organization, table of contents.
Jones et al., 1994, Hum. Mol. Genet. 3:2123-2130.
Jones et al., 1995, Nature 376:145-149.
Kastury et al., 1996, Genomics 32:225-235.
Kastury et al., 1996, Cancer Res. 56:978-983.
Killary et al., 1992, Proc. Natl. Acad. Sci. USA 89:10877-10881.
Kim et al., 1993, Am. J. Pathol. 142:307-317.
Kok et al., 1987, Nature 330:578-581.
Kok et al., 1993, Proc. Natl. Acad. Sci. USA 90:6071-6075.
Kok et al., 1994, Cancer Res. 54:4183-4187.
Kok et al., 1995, Cytogenet. Cell Genet. 68:144.
Knight et al., 1993, Cell 74:127-134.
Kremer et al., 1991, Science 252:1711-1714.
Kuzmin et al., 1995, Cytogenet. Cell Genet. 68:145.
LaForgia et al., 1991, Proc. Natl. Acad. Sci. USA 88:5036-5040.
LaForgia et al., 1993, Cancer Res. 53:3118-3124.
Li et al., 1993, Annals of Internal Med. 118(2):106-111.
Leach et al., 1995, Cytogenet. Cell Genet. 68:140.
Lisitsyn et al., 1993, Science 259:946-951.
Lisitsyn et al., 1995, Proc. Natl. Acad. Sci. USA 92:151-155.
Lo et al., 1994, Int. J. Oncol. 4:1359-1364.
Lubinski et al., 1994, Cancer Res. 54:3710-3713.
Lux et al., 1995, Cytogenet. Cell Genet. 68:142.
Maher, 1995, Cytogenet. Cell Genet. 68:145.
Mahyer, 1995, Cytogenet. Cell Genet. 68:145.
McAlpine et al., 1995, Cytogenet. Cell Genet. 68:146.
Michaelis et al., 1995, Cancer Genet. Cytogenet. 81:1-12.
Mitsudomi et al., 1992, Oncogene 7:171-180.
Mozier et al., 1991, FEBS 279(1):14-18.
Murata et al., 1992, Jpn. J. Hum. Genet. 37:205-213.
Murray et al., 1995, Cytogenet. Cell Genet. 68:140.
Naylor et al., 1987, Nature 329:451-454.
O'Connell et al., 1995, Cytogenet. Cell Genet. 68:137.
Ohta et al., 1995, Int. J. Cancer 65:762-767.
Ohta et al., Feb. 23, 1996, Cell 84(4):587-597.
Paradee et al., 1995, Genomics 27:358-361.
Paradee et al., 1995, Cytogenet. Cell Genet. 68:143.
Pathak et al., 1995, Cancer Genet. Cytogenet. 83:172-173.
Pearson et al., 1990, J. Biol. Chem. 265(8):4583-4591.
Pekarsky et al., 1995, Cytogenet. Cell Genet. 68:144-145.
Rabbitts et al., 1989, Genes Chrom. Cancer 1:95-105.
Rabbitts et al., 1990, Gene Chrom. Cancer 2:231-238.
Rassool et al., 1992, Am. J. Hum. Genet. 50:1243-1251.
Rassool et al., 1995, Cytogenet. Cell Genet. 68:142-143.
Reichel et al., 1994, Mol. Carcinog. 9:105-109.
Roche et al., 1994, Hum. Mol. Genet. 3:215.
Sanchez et al., 1995, Cytogenet. Cell Genet. 68:146.
Schnittger, 1995, Cytogenet Cell Genet. 68:142.
Sekido et al., 1994, Oncogene 9:1599-1604.
Seraphin, 1992, J. DNA Sequencing & Mapping 3:177-179.
Shridhar et al., 1995, Cytogenet. Cell Genet. 68:144.
Smith et al., 1995, Cytogenet. Cell Genet. 68:126-146.
Sozzi et al., 1991, Cancer Res. 51:400-404.
Sundaresan et al., 1992, Oncogene 7:1989-1997.
Sutherland, 1991, Genet. Anal. Tech. Appl. 8(6):1616-166.
Takahashi et al., 1989, Science 246:491-494.
Testa et al., 1994, Genes Chrom. Cancer 11:178-194.
Thorne et al., 1995, Biochem. J. 311:717-721.
van den Berg et al., 1995, Cytogenet. Cell Genet. 68:144.
Verkerk et al., 1991, Cell 65:905-914.
Wang and Perkins, 1984, Cancer Genet. Cytogenet. 11:479-481.
Wang et al., 1993, Genomics 17:341-347.
Wary et al., 1993, Cancer Res. 53:1498-1502.
Weinmann-Dorsch et al., 1984, Eur. J. Biochem. 138:179-185.
WhangPeng et al., 1982, Science 215:181-182.
Wilhelm et al., 1995, Cancer Res. 55:5383-5385.
Wilke et al., 1994, Genomics 22:319-326.
Wilke et al., 1995, Cytogenet. Cell Genet. 68:143.
World Health Organization, 1981, "Histological typing of lung tumors," 2nd ed., Geneva:World Health Organization, table of contents.
Xu et al., 1994, J. Natl. Cancer Inst. 86(9):695-699.
Yang, 1980, Cancer Res. 40:2633-2644.
Yang et al., 1987 J. Natl. Cancer Inst. 79(6):1241-1246.
Yokota et al., 1987, Proc. Natl. Acad. Sci. USA 84:9252-9256.
Yokota et al., 1989, Cancer Res. 49:3598-3601.
Yokoyama et al., 1992, Cancer Res. 52:873-877.
Yu et al., 1991, Science 252:1179-1181.
Yunis and Soreng, 1984, Science 226:1199-1204.
Zabarovsky et al., 1995, Cytogenet. Cell Genet. 68:141.
Zahkaryev et al., 1995, Cytogenet. Cell Genet. 68:141.

Affiliated with

Also associated with

Rating

FHIT proteins and nucleic acids and methods based thereon does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with FHIT proteins and nucleic acids and methods based thereon, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and FHIT proteins and nucleic acids and methods based thereon will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-877543