FGF2-binding peptides and uses thereof

Details FGF2-binding peptides and uses thereof FGF2-binding peptides and uses thereof

2007-01-23

2011-12-13

Allen, Marianne P (Department: 1647)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C530S324000, C530S327000, C530S330000, C514S009100, C514S021600, C514S021500, C514S021300

Reexamination Certificate

active

08076300

ABSTRACT:
FGF2-binding peptides are here described, which have been designed starting from the N-terminal region of PTX3, in particular spanning the PTX3(82-11O) region. Synthetic peptides related to this sequence are able to bind FGF2and to inhibit its pro-angiogenic activity in vitro and in vivo with no anticipated impact on innate immunity.

REFERENCES:
patent: 2008/0015153 (2008-01-01), Bottazzi et al.
patent: WO 02/38169 (2002-05-01), None
patent: WO 03/072603 (2003-09-01), None
Marco Rusnati et al. “Selective recognition of fibroblast growth factor-2 by the long pentraxin PTX3 inhibits angiogenesis” in Blood, Jul. 1, 2004, vol. 104, No. 1, pp. 92-99, ISSN: 0006-4971.
Marco Rusnati et al. “Fibroblast growth factor/fibroblast growth factor receptor system in angiogenesis” in Cytokine Growth Factor Reviews, Apr. 2005, pp. 159-178, ISSN: 1359-6101.
Catherine Perollet et al. “Platelet factor 4 modulates fibroblast growth factor 2 (FGF-2) activity and inhibits FGF-2 dimerization” in Blood, vol. 91 No. 9, pp. 3289-3299, May 1, 1998, ISSN: 0006-4971.
Maura Camozzi et al. “Pentraxin 3 inhibits fibroblast growth factor 2-dependent activation of smooth muscle cells in vitro and neointima formation in vivo” in Arteriosclerosis, Thrombosis, and Vascular Biology, pp. 1837-1842, Sep. 2005, ISSN: 1524-4636.
Maura Camozzi et al. “Identification of an antiangiogenic FGF-2binding site in the N terminus of the soluble pattern recognition receptor PTX3” in The Journal of Biological Chemistry, pp. 22605-22613, Aug. 11, 2006, ISSN: 0021-9258.

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